Author | Tort, Luis Fernando Lopez | |
Author | Ribeiro, Ieda Pereira | |
Author | Menezes, Lidiane Souza Raphael | |
Author | Santos, Alexandre Araújo Cunha dos | |
Author | Santos, Marta Pereira | |
Author | Damasceno, Luana | |
Author | Silva, Paola Cristina Resende | |
Author | Siqueira, Marilda Agudo Mendonça Teixeira de | |
Author | Brasil, Patricia | |
Author | Bonaldo, Myrna Cristina | |
Access date | 2021-11-14T12:53:21Z | |
Available date | 2021-11-14T12:53:21Z | |
Document date | 2021 | |
Citation | TORT, Luis Fernando Lopez et al. SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210166, p. 1-4, 2021. | pt_BR |
ISSN | 0074-0206 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/49831 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | SARS-CoV-2 | pt_BR |
Subject in Portuguese | COVID-19 | pt_BR |
Subject in Portuguese | Variantes de interesse | pt_BR |
Subject in Portuguese | Linhagem N.9 | pt_BR |
Subject in Portuguese | E484K | pt_BR |
Subject in Portuguese | Rio de Janeiro | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760210166 | |
Abstract | BACKGROUND The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.33-derived lineage named N.9 was
described recently in Brazil and it’s considered a potential variant of interest (VOI) due to the presence of E484K substitution at
the receptor-binding domain (RBD) of the Spike (S) protein.
OBJECTIVE To describe the first detection of variant N.9 in Rio de Janeiro State.
METHODS SARS-CoV-2 N.9 was confirmed by quantitative reverse transcription polymerase chain reaction (qRT-PCR), wholegenome sequencing and phylogenetic analysis.
FINDINGS Here, we report two SARS-CoV-2 N.9 lineage strains in Rio de Janeiro. One of them had only the E484K substitution
of the six N.9 lineage-defining mutations. Other three strains pre-defined as N.9 have the same genomic profile. These four
strains are grouped within the B.1.1.33 lineage and basal to the N.9 lineage in our phylogenetic analysis, and we call them “N.9-
like/B.1.1.33 + E484K”.
MAIN CONCLUSIONS The phylogenetic analysis shows four independent introductions of N.9 in the state of Rio de Janeiro in
October and December 2020, January and March 2021. SARS-CoV-2 N.9 dissemination in the Rio de Janeiro could have been
limited by the emergence and dominance of other variants, mainly by the lineage P.2 VOI Zeta that emerged in the same period
and co-circulated with N.9, as observed in the neighboring State of São Paulo. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidad de la República. Centro Universitario Regional Litoral Norte. Laboratorio de Virología Molecular. Salto, Uruguay. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | SARS-CoV-2 | pt_BR |
Subject | COVID-19 | pt_BR |
Subject | Variants of interest | pt_BR |
Subject | Lineage N.9 | pt_BR |
Subject | E484K | pt_BR |
Subject | Rio de Janeiro | pt_BR |
Subject | Brazil | pt_BR |
e-ISSN | 1678-8060 | |