| Author | Gomes, Carolina N. | |
| Author | Campioni, Fábio | |
| Author | Vilela, Felipe P. | |
| Author | Duque, Sheila S. | |
| Author | Falcão, Juliana P. | |
| Access date | 2021-11-17T13:05:32Z | |
| Available date | 2021-11-17T13:05:32Z | |
| Document date | 2021 | |
| Citation | GOMES, Carolina N. et al. Campylobacter coli strains from Brazil can invade phagocytic and epithelial cells and induce IL-8 secretion. Brazilian Journal of Microbiology, v. 52, n. 2, p. 859-867, Feb, 2021. | pt_BR |
| ISSN | 1678-4405 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49854 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Microbiologia | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Patógenos de origem alimentar | pt_BR |
| Subject in Portuguese | Linhas celulares Caco-2 e U-937 | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Campylobacter coli strains from Brazil can invade phagocytic and epithelial cells and induce IL-8 secretion | pt_BR |
| Type | Article | |
| DOI | 10.1007/s42770-021-00450-1 | |
| Abstract | Campylobacter spp. have been a predominant cause of bacterial foodborne gastroenteritis worldwide, causing substantial costs to
public healthcare systems. This study aimed to assess the invasion and pro-inflammatory cytokine production capacity of
Campylobacter coli strains isolated in Brazil. A total of 50 C. coli isolated from different sources in Brazil were analyzed for
their capacity of invasion in Caco-2 and U-937 cell lines. The production of pro-inflammatory cytokines was quantitatively
measured in response to C. coli. All the strains studied showed invasion percentage ≥ 40% in polarized Caco-2 cells. In U-937
cells assay, 35 of 50 C. coli strains studied showed invasion percentage ≥ 50%. A significant increase in IL-8 production by
infected U-937 cells was observed for 17.5% of the C. coli isolates. The high percentages of invasion in Caco-2 and U-937 cells
observed for all studied strains, plus the increased production of IL-8 by U-937 cells against some strains, highlighted the
pathogenic potential of the C. coli studied and bring extremely relevant data since it has never been reported for strains isolated
in Brazil and there are a few data for C. coli in the literature. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil. | pt_BR |
| Subject | Foodborne pathogens | pt_BR |
| Subject | Caco-2 and U-937 cell lines | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Brazil | pt_BR |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
