| Author | Lago, Tainã | |
| Author | Carvalho, Lucas P. | |
| Author | Nascimento, Mauricio | |
| Author | Guimarães, Luiz H. | |
| Author | Lago, Jamile | |
| Author | Castellucci, Léa | |
| Author | Carvalho, Augusto M. | |
| Author | Lago, Alex | |
| Author | Carvalho, Edgar Marcelino de | |
| Access date | 2021-11-17T17:57:38Z | |
| Available date | 2021-11-17T17:57:38Z | |
| Document date | 2021 | |
| Citation | LAGO, Tainã et al. Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Clinical Infectious Diseases, 2021. | pt_BR |
| ISSN | 1058-4838 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49860 | |
| Sponsorship | Brazilian Ministry
of Science, Technology, and Innovation; the Brazilian Research Council
(CNPq); and the Fundação de Amparo à Pesquisa do Estado da Bahia
(FAPESB). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmaniose cutânea | pt_BR |
| Subject in Portuguese | Leishmania braziliensis | pt_BR |
| Subject in Portuguese | Obesidade | pt_BR |
| Subject in Portuguese | Lesões atípicas | pt_BR |
| Subject in Portuguese | Resposta imune. | pt_BR |
| Title | Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/cid/ciab236 | |
| Abstract | Background. Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a single ulcer or multiple cutaneous
lesions with raised borders. Cure rates <60% are observed in response to meglumine antimoniate therapy. We investigated
the impact of obesity on CL clinical presentation and therapeutic response.
Methods. A total of 90 age-matched patients with CL were included (30 obese, 30 overweight, and 30 with normal body mass
index [BMI]). CL was diagnosed through documentation of L. braziliensis DNA by polymerase chain reaction or identification of
amastigotes in biopsied skin-lesion samples. Serum cytokine levels were determined by chemiluminescence. Antimony therapy with
Glucantime (Sanofi-Aventis; 20 mg/kg/day) was administered for 20 days.
Results. Obese CL patients may present hypertrophic ulcers rather than typical oval, ulcerated lesions. A direct correlation between
BMI and healing time was noted. After 1 course of antimony, cure was achieved in 73% of patients with normal BMI, 37%
of overweight subjects, yet just 18% of obese CL patients (P < .01). Obese CL cases additionally presented higher leptin levels than
overweight patients or those with normal BMI (P < .05).
Conclusions. Obesity modifies the clinical presentation of CL and host immune response and is associated with greater failure
to therapy. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
| Affilliation | Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
| Affilliation | Federal University of Southern Bahia. Teixeira de Freitas, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
| Subject | cutaneous Leishmaniasis; | pt_BR |
| Subject | Leishmania braziliensis | pt_BR |
| Subject | Obesity | pt_BR |
| Subject | Atypical lesions | pt_BR |
| Subject | Immune response. | pt_BR |
