| Author | Arteaga-Blanco, Luis A. | |
| Author | Bou-Habib, Dumith Chequer | |
| Access date | 2021-11-18T20:48:40Z | |
| Available date | 2021-11-18T20:48:40Z | |
| Document date | 2021 | |
| Citation | ARTEAGA-BLANCO, Luis A. ; BOU-HABIB, Dumith Chequer. The Role of Extracellular Vesicles from Human Macrophages on Host-Pathogen Interaction. International Journal of Molecular Sciences, v. 22, 10262, p. 1-19, Sept. 2021. | pt_BR |
| ISSN | 1422-0067 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49879 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vesículas extracelulares | pt_BR |
| Subject in Portuguese | Macrófagos humanos | pt_BR |
| Subject in Portuguese | Imunidade inata | pt_BR |
| Subject in Portuguese | Interação hospedeiro-patógeno e doenças infecciosas | pt_BR |
| Title | The Role of Extracellular Vesicles from Human Macrophages on Host-Pathogen Interaction | pt_BR |
| Type | Article | |
| DOI | 10.3390/ ijms221910262 | |
| Abstract | The nano-sized membrane enclosed extracellular vesicles (EVs) released by virtually all
cell types play an essential role in intercellular communication via delivering bio-molecules, such
as nucleic acids, proteins, lipids, and other molecules to recipient cells. By mediating an active
and steady-state cell-to-cell communication, EVs contribute to regulating and preserving cellular
homeostasis. On the other hand, EVs can also spread pathogen-derived molecules during infections,
subverting the host immune responses during infections and thus worsening pathophysiological
processes. In recent years, the biological functioning of EVs has become a widespread research
field in basic and clinical branches of medical sciences due to their potential role in therapeutic
applications for several diseases. This review aims to summarize the main recent findings regarding
the implication of EVs shed by human macrophages (MF-EVs) and how they can modulate the host
immune response to control or increase the damage caused by infectious agents. We will also present
the methods used to describe MF-EVs, as well as the potential of these EVs as disease diagnostic
tools for some human pathogens. We believe that an in-depth understanding of the host–pathogen
interactions mediated by MF-EVs may trigger the development of innovative therapeutic strategies
against infectious diseases. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Extracellular vesicles | pt_BR |
| Subject | Human macrophages | pt_BR |
| Subject | Innate immunity | pt_BR |
| Subject | Host–pathogen interaction and infectious diseases | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
