| Author | Mangia, L.H.R. | |
| Author | Ferraz, H. C. | |
| Author | Souza, R. S. D. | |
| Author | Pereira, M. C. S. | |
| Author | Pinto, J. C. | |
| Access date | 2021-11-19T12:14:15Z | |
| Available date | 2021-11-19T12:14:15Z | |
| Document date | 2021 | |
| Citation | MANGIA, L. H. R. et al. In situ encapsulation of rivastigmine in TAT-functionalized P(MMA-co-AA) nanoparticles through miniemulsion polymerization. Colloids and Surfaces A: Physicochemical and Engineering Aspects, v. 624, 126776, p. 1-11, May 2021. | pt_BR |
| ISSN | 0927-7757 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49881 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Encapsulamento | pt_BR |
| Subject in Portuguese | Rivastigmina | pt_BR |
| Subject in Portuguese | Poli (metacrilato de metila-ácido co-acrílico) | pt_BR |
| Subject in Portuguese | Funcionalização química | pt_BR |
| Subject in Portuguese | Polimerização em miniemulsão | pt_BR |
| Subject in Portuguese | Doença de Alzheimer | pt_BR |
| Title | In situ encapsulation of rivastigmine in TAT-functionalized P(MMA-co-AA) nanoparticles through miniemulsion polymerization | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.colsurfa.2021.126776 | |
| Abstract | The present study aimed to encapsulate rivastigmine (a drug used for treatment of the Alzheimer disease) in poly
(methyl methacrylate – co – acrylic acid), P(MMA-co-AA), nanoparticles functionalized with the transcription
activator peptide (TAT) for biomedical applications. Encapsulation was performed in situ through miniemulsion
polymerization at different preparation conditions and the highest encapsulation efficiencies (around 80%) were
obtained when the comonomer mixture contained 7.5 wt% of acrylic acid in methyl methacrylate. Afterwards,
functionalization trials of the previously prepared polymer nanoparticles were performed through chemical
adsorption, leading to high TAT immobilization efficiencies (94%). Additionally, toxicity bioassays conducted
with Caco-2 cells monolayers revealed that the cytotoxicity of obtained particles was low and did not depend on
the nanoparticle composition. Besides, the obtained results indicated that the functionalized nanoparticles could
cross the intestinal epithelial barrier successfully. Finally, the obtained particles presented good stability, could
be prepared with high encapsulation and functionalization efficiencies, and presented advantageous biological
properties that encourage the future development of biomedical uses. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Programa de Engenharia Química/COPPE. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Programa de Engenharia Química/COPPE. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Programa de Engenharia Química/COPPE. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Encapsulation | pt_BR |
| Subject | Rivastigmine | pt_BR |
| Subject | Poly(methyl methacrylate-co-acrylic acid) | pt_BR |
| Subject | Chemical functionalization | pt_BR |
| Subject | Miniemulsion polymerization | pt_BR |
| Subject | Alzheimer disease | pt_BR |
| Embargo date | 2023 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
