| Author | Silva, Taylon Felipe | |
| Author | Tomiotto-Pellissier, Fernanda | |
| Author | Pasquali, Aline Kuhn Sbruzzi | |
| Author | Pinto-Ferreira, Fernanda | |
| Author | Pavanelli, Wander Rogério | |
| Author | Conchon-Costa, Ivete | |
| Author | Navarro, Italmar Teodorico | |
| Author | Caldart, Eloiza Teles | |
| Access date | 2021-11-25T17:56:30Z | |
| Available date | 2021-11-25T17:56:30Z | |
| Document date | 2021 | |
| Citation | SILVA, Taylon Felipe et al. Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review. Acta Tropica. v. 221, n. 106018, p. 1–8, 2021. | pt_BR |
| ISSN | 0001-706X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50065 | |
| Language | por | pt_BR |
| Publisher | Acta Tropica | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmania amazonensis | pt_BR |
| Title | Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.actatropica.2021.106018 | |
| Abstract | Leishmania (Leishmania) amazonensis is an important etiological agent of American cutaneous leishmaniasis
(ACL) in Brazil. The species causes a large spectrum of clinical manifestations in humans and dogs, ranging from cutaneous, cutaneous diffuse, mucocutaneous, and visceral involvement, however, the factors that drive the development of different disease forms by the same species are not yet fully known. In the present work, it was systematically reviewed the studies addressing phenotypic and genotypic characteristics of Leishmania (L.) amazonensis isolates causing cutaneous and visceral clinical frames in humans and dogs, comparing the results observed. For this, four research databases were searched for the following keywords: (Leishmania amazonensis AND visceral leishmaniasis) AND (tropism OR virulence OR visceralization OR adaptations OR mutation OR clinical presentation OR resistance OR survival OR wide spectrum). The results revealed that the complexity disease seems to involve the combination of genetic factors of the parasite (as modifications in molecules related to the virulence and metabolism) and also of the host’s immune background and status. Nonetheless, the exact mechanism that leads to different clinical manifestations between strains of the same species is still uncertain and future studies must be developed to better elucidate this phenomenon. | pt_BR |
| Affilliation | Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade do Oeste de Santa Catarina. Campos Novos, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Londrina. Centro de Ciências Agrárias. Departamento de Medicina Veterinária Preventiva. Londrina, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Londrina. Centro de Ciências Agrárias. Departamento de Medicina Veterinária Preventiva. Londrina, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Londrina. Centro de Ciências Agrárias. Departamento de Medicina Veterinária Preventiva. Londrina, PR, Brasil. | pt_BR |
| Subject | Leishmaniasis, Cutaneous | pt_BR |
| Subject | Leishmaniasis, Visceral | pt_BR |
| Subject | Virulence | pt_BR |
| Subject in Spanish | Leishmaniasis Cutánea | pt_BR |
| Subject in Spanish | Leishmaniasis Visceral | pt_BR |
| Subject in Spanish | Virulencia | pt_BR |
| Subject in French | Leishmaniose cutanée | pt_BR |
| Subject in French | Leishmaniose viscérale | pt_BR |
| Subject in French | Virulence | pt_BR |
| DeCS | Leishmaniose Cutânea | pt_BR |
| DeCS | Leishmaniose Visceral | pt_BR |
| DeCS | Virulência | pt_BR |
