| Author | Ismerim, Adna Barros | pt_BR |
| Author | Araújo, Iguaracyra B. de Oliveira | pt_BR |
| Author | Xavier, Flávia C. de Aquino | pt_BR |
| Author | Rocha, Clarissa Araujo Gurgel | pt_BR |
| Author | Macedo, Cláudia L. | pt_BR |
| Author | Cangussu, Maria C.T. | pt_BR |
| Author | Freitas, Valéria S. | pt_BR |
| Author | Della Coletta, Ricardo | pt_BR |
| Author | Cury, Patrícia R. | pt_BR |
| Author | Santos, Jean N. | pt_BR |
| Access date | 2021-12-06T13:31:42Z | |
| Available date | 2021-12-06T13:31:42Z | |
| Document date | 2021 | |
| Citation | ISMERIM, Adna Barros et al. Mast cells and proteins related to myofibroblast differentiation (PAR-2, IL-6, and TGFβ1) in salivary cancers: a preliminary study. Applied Immunohistochemistry and Molecular Morphology, v. 29, n. 7, p. e57-e67, 2021. | pt_BR |
| ISSN | 1541-2016 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50178 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | pt_BR |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES) | pt_BR |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Glândula salivar | pt_BR |
| Subject in Portuguese | Neoplasias | pt_BR |
| Subject in Portuguese | Miofibroblastos | pt_BR |
| Title | Mast cells and proteins related to myofibroblast differentiation (PAR-2, IL-6, and TGFβ1) in salivary cancers: a preliminary study | en_US |
| Type | Article | |
| DOI | 10.1097/PAI.0000000000000924 | pt_BR |
| Abstract | Salivary gland neoplasms represent an important group of cancers in the head and neck and myoepithelial cells play a key role on the development these tumors. This study evaluated the distribution of mast cells and related proteins (PAR-2, TGFβ1, IL-6) to the myofibroblastic differentiation in malignant tumors of salivary glands with and without myoepithelial differentiation. Immunohistochemical assessement for tryptase mast cells, SMA, PAR-2, TGFβ1, IL-6 was performed in 10 cases of polymorphous low-grade adenocarcinoma, 14 cases of mucoepidermoid carcinoma (MEC) and 10 cases of adenoid cystic carcinoma. When the density of mast cells were compared between tumors, their density was significantly higher in MEC (P= 0.08). Tumors with high expression of PAR-2 (79.4%) exhibited a high density of mast cells. Myofibroblasts were more frequent in malignant tumors with low expression (<50%) of cell masts. Individual analysis of the tumors showed no significant difference between the expression of PAR-2, IL-6, TGFβ1, and myofibroblasts. When the density of mast cells, myofibroblasts and the expression of PAR-2 protein, IL-6, and TGFβ1 were compared, it was no statistically significant difference between tumors with and without myoepithelial differentiation. The results of present study suggest a possible participation of mast cells and especially of PAR-2 in the development and progression of malignant salivary cancers, regardless of myoepithelial content. | en |
| Affilliation | Universidade Estadual do Sudoeste da Bahia. Departamento de Saúde. Faculdade de Odontologia. Jequié, BA, Brasil. | pt_BR |
| Affilliation | Hospital Aristides Maltez. Departamento de Patologia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Odontologia. Laboratório de Patologia Cirúrgica. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Laboratório Micro. Vitória da Conquista, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Feira de Santana. Departamento de Saúde. Faculdade de Odontologia. Feira de Santana, BA, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Piracicaba, SP, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Feira de Santana. Departamento de Saúde. Faculdade de Odontologia. Departamento de Periodontia. Feira de Santana, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Odontologia. Laboratório de Patologia Cirúrgica. Salvador, BA, Brasil. | pt_BR |
| Subject | Salivary gland | en |
| Subject | Neoplasms | en |
| Subject | Mast cell | en |
| Subject | Myofibroblast | en |
| e-ISSN | 1533-4058 | pt_BR |
