Author | Neiva, Vanessa Lima | |
Author | Toma, Helena Keiko | |
Author | Aguiar, Lúcia Maria Abrantes | |
Author | Lopes, Catarina Macedo | |
Author | Dias, Letícia Paschoaletto | |
Author | Gonçalves, Teresa Cristina Monte | |
Author | Costa, Jane | |
Access date | 2021-12-07T13:22:03Z | |
Available date | 2021-12-07T13:22:03Z | |
Document date | 2021 | |
Citation | NEIVA, Vanessa Lima et al. The connection between Trypanosoma cruzi transmission cycles by Triatoma brasiliensis brasiliensis: A threat to human health in an area susceptible to desertification in the Serido´, Rio Grande do Norte, Brazil. Plos Negl. Trop. Dis, v. 15, n. 11, e0009919, p. 1 - 21, Nov. 2021. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50199 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Ciclos de transmissão | pt_BR |
Subject in Portuguese | Triatoma brasiliensis brasiliensis | pt_BR |
Subject in Portuguese | Saúde humana | pt_BR |
Subject in Portuguese | Área suscetível à desertificação | pt_BR |
Subject in Portuguese | Seridó, Rio Grande do Norte | pt_BR |
Title | The connection between Trypanosoma cruzi transmission cycles by Triatoma brasiliensis brasiliensis: A threat to human health in an area susceptible to desertification in the Serido´, Rio Grande do Norte, Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal. pntd.0009919 | |
Abstract | An outbreak of Chagas disease, possibly involving its vector Triatoma brasiliensis brasiliensis,
was identified in the state of Rio Grande do Norte (RN). Given the historical significance
of this vector in public health, the study aimed to evaluate its role in the transmission dynamics
of the protozoan Trypanosoma cruzi in an area undergoing desertification in the Serido´
region, RN, Brazil. We captured triatomines in sylvatic and anthropic ecotopes. Natural vector
infection was determined using parasitological and molecular methods and we identified
discrete typing units (DTUs) of T. cruzi by analyzing the COII gene of mtDNA, 24Sα rDNA,
and mini-exon gene. Their blood meals sources were identified by amplification and
sequencing of the mtDNA cytochrome b gene. A total of 952 T. b. brasiliensis were captured
in peridomestic (69.9%) and sylvatic ecotopes (30.4%). A wide range of natural infection
rates were observed in peridomestic (36.0% - 71.1%) and sylvatic populations (28.6% -
100.0%). We observed the circulation of TcI and TcII DTUs with a predominance of Tcl in
sylvatic and peridomestic environments. Kerodon rupestris, rocky cavy (13/39), Homo sapiens,
human (8/39), and Bos taurus, ox (6/39) were the most frequently detected blood
meals sources. Thus, Triatoma b. brasiliensis is invading and colonizing the human dwellings.
Furthermore, high levels of natural infection, coupled with the detection of TcI and TcII
DTUs, and also the detection of K. rupestris and H. sapiens as blood meals sources of
infected T. b. brasiliensis indicate a risk of T. cruzi transmission to human populations in
areas undergoing desertification. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biodiversidade Entomológica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Laboratório de Diagnóstico Molecular e Hematologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Secretaria de Estado da Saúde Pública. Natal, RN, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Vigilância Entomológica em Diptera e Hemiptera. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biodiversidade Entomológica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Vigilância Entomológica em Diptera e Hemiptera. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biodiversidade Entomológica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Transmission cycles | pt_BR |
Subject | Triatoma brasiliensis brasiliensis | pt_BR |
Subject | Human health | pt_BR |
Subject | Area susceptible desertification | pt_BR |
Subject | Seridó, Rio Grande do Norte | pt_BR |
Subject | Brasil | pt_BR |