| Author | Carneiro, Pedro Paulo | |
| Author | Dórea, Andreza S. | |
| Author | Oliveira, Walker N. | |
| Author | Guimarães, Luiz Henrique | |
| Author | Brodskyn, Claúdia Ida | |
| Author | Carvalho, Edgar Marcelino de | |
| Author | Bacellar, Olıvia | |
| Access date | 2021-12-09T12:56:28Z | |
| Available date | 2021-12-09T12:56:28Z | |
| Document date | 2021 | |
| Citation | CARNEIRO, Pedro Paulo et al. Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis. Frontiers in Immunology, 2021. | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50231 | |
| Sponsorship | National Institutes of Health (AI
136032 to EC). EC and OB are senior researchers at the Brazilian
Council for Scientific and Technological Development
(Conselho Nacional de Desenvolvimento Cientı́fico e
Tecnológico (CNPq). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Imunidade inata | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Leishmaniose cutânea | pt_BR |
| Subject in Portuguese | Leishmania braziliensis | pt_BR |
| Subject in Portuguese | Receptores toll-like | pt_BR |
| Title | Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3389/fimmu.2021.706510 | |
| Abstract | Human cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by
a pronounced inflammatory response associated with ulcer development. Monocytes/
macrophages, the main cells harboring parasites, are largely responsible for parasite
control. Toll-like receptor (TLR) signaling leads to the transcription of inflammatory
mediators, such as IL-1b and TNF during innate immune response. TLR antagonists
have been used in the treatment of inflammatory disease. The neutralization of these
receptors may attenuate an exacerbated inflammatory response.We evaluated the ability of
TLR2 and TLR4 antagonists to modulate host immune response in L. braziliensis-infected
monocytes and cells from CL patient skin lesions. Following TLR2 and TLR4 neutralization,
decreased numbers of infected cells and internalized parasites were detected in CL patient
monocytes. In addition, reductions in oxidative burst, IL-1b, TNF and CXCL9 production
were observed. TNF production by cells from CL lesions also decreased after TLR2 and
TLR4 neutralization. The attenuation of host inflammatory response after neutralizing these
receptors suggests the potential of TLR antagonists as immunomodulators in association
with antimonial therapy in human cutaneous leishmaniasis | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Sul da Bahia. Faculdade de Medicina. Teixeira de Freitas, BA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia. Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Estatal Saúde da Família. Instituto Gonçalo Moniz. Fundação Oswaldo Cruz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Estatal Saúde da Família. Instituto Gonçalo Moniz. Fundação Oswaldo Cruz. Salvador, BA, Brasil. | pt_BR |
| Subject | innate immunity | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Cutaneous leishmaniasis | pt_BR |
| Subject | Leishmania braziliensis | pt_BR |
| Subject | Toll-like receptors | pt_BR |
