| Author | Nunes, Estéfane da C. | |
| Author | Filippis, Ana M. B. de | |
| Author | Pereira, Taiane do E. S. | |
| Author | Faria, Nieli R. da C. | |
| Author | Salgado, Álvaro | |
| Author | Santos, Cleiton S. | |
| Author | Carvalho, Teresa C. P. X. | |
| Author | Calcagno, Juan I. | |
| Author | Chalhoub, Flávia L. L. | |
| Author | Brown, David | |
| Author | Giovanetti, Marta | |
| Author | Alcantara Junior, Luiz Carlos | |
| Author | Barreto, Fernanda K. | |
| Author | Siqueira, Isadora Cristina de | |
| Author | Canuto, Gisele A. B. | |
| Access date | 2021-12-09T17:31:49Z | |
| Available date | 2021-12-09T17:31:49Z | |
| Document date | 2021 | |
| Citation | NUNES, Estéfane da C. et al. Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection. Pathogens, 2021. | pt_BR |
| ISSN | 2076-0817 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50255 | |
| Description | 1 Departamento de Química Analítica, Instituto de Química, Universidade Federal da Bahia, Rua Barao de
Jeremoabo, 147, Salvador, BA 40170-115, Brazil; estefane.cruz@gmail.com (E.d.C.N.);
taianepereira94@gmail.com (T.d.E.S.P.)
2 Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro,
RJ 21040-900, Brazil; ana.bispo@ioc.fiocruz.br (A.M.B.d.F.); flaviallevy@yahoo.com.br (F.L.L.C.);
David.Brown@phe.gov.uk (D.B.); giovanetti.marta@gmail.com (M.G.); luiz.alcantara@ioc.fiocruz.br (L.C.J.A.)
3 Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Avenida Presidente
Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil; alvaro.salgado.81@gmail.com
4 Instituto Gonçalo Moniz, Fiocruz, Rua Waldemar Falcão, 121, Salvador, BA 40295-010, Brazil;
Cleitonsantos29@outlook.com
5 Maternidade de Referência Professor José Maria de Magalhães Neto, SESAB, Rua Marquês de Maricá,
Salvador, BA 40310-000, Brazil; terezaxpaim@gmail.com (T.C.P.X.C.); calcagnoji@gmail.com (J.I.C.)
6 Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Vitória da
Conquista, BA 45029-094, Brazil | pt_BR |
| Sponsorship | Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro
(FAPERJ) under the grant number E-26/2002.930/2016, by the Canadian International Development
Research Centre (IDRC), grant number 108411-001. I.C.S was supported by the Conselho Nacional de
Desenvolvimento Científico e Tecnológico (CNPq) grant number 443875/2018-9 and the Fundação
de Amparo à Pesquisa do Estado da Bahia (FAPESB) grant number 5125/2017). | pt_BR |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Vírus Zika | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Metabolômica | pt_BR |
| Subject in Portuguese | Aprendizado de máquina | pt_BR |
| Title | Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3390/ pathogens10040468 | |
| Abstract | Abstract: Zika virus (ZIKV), an emerging virus belonging to the Flaviviridae family, causes severe
neurological clinical complications and has been associated with Guillain-Barré syndrome, fetal
abnormalities known collectively as congenital Zika syndrome, and microcephaly. Studies have
shown that ZIKV infection can alter cellular metabolism, directly affecting neural development.
Brain growth requires controlled cellular metabolism, which is essential for cell proliferation and
maturation. However, little is known regarding the metabolic profile of ZIKV-infected newborns and
possible associations related to microcephaly. Furthering the understanding surrounding underlying
mechanisms is essential to developing personalized treatments for affected individuals. Thus,
metabolomics, the study of the metabolites produced by or modified in an organism, constitutes a
valuable approach in the study of complex diseases. Here, 26 serum samples from ZIKV-positive
newborns with or without microcephaly, as well as controls, were analyzed using an untargeted
metabolomics approach involving gas chromatography–mass spectrometry (GC-MS). Significant
alterations in essential and non-essential amino acids, as well as carbohydrates (including aldohexoses,
such as glucose or mannose) and their derivatives (urea and pyruvic acid), were observed in the
metabolic profiles analyzed. Our results provide insight into relevant metabolic processes in patients
with ZIKV and microcephaly. | pt_BR |
| Affilliation | “Múltipla – ver em notas” | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Metabolomics | pt_BR |
| Subject | Machine learning | pt_BR |
| xmlui.metadata.dc.subject.ods | 04 Educação de qualidade | |
