| Author | Santos, José Augusto Albuquerque | |
| Author | Gomes, Keyla Nunes Farias | |
| Author | Lima, Lucas Vinicius | |
| Author | Faria, Robson Xavier | |
| Access date | 2021-12-09T20:05:53Z | |
| Available date | 2021-12-09T20:05:53Z | |
| Document date | 2021 | |
| Citation | SANTOS, José Augusto Albuquerque et al. Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory. Open Access Journal of Biomedical Science, v. 4, n. 6, p. 1208-1214, 2021. | pt_BR |
| ISSN | 2690-487X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50262 | |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Plectranthus grandis | pt_BR |
| Subject in Portuguese | Esquistossomíase | pt_BR |
| Subject in Portuguese | Produtos naturais | pt_BR |
| Title | Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory | pt_BR |
| Type | Article | |
| DOI | 10.38125/OAJBS.000333 | |
| Abstract | The objective of this work was to test the bioactivity of the different extracts and fractions of the leaves of Plectranthus grandis
and to determine their lethal concentrations on Biomphalaria glabrata. For the bioassays, seven crude extracts obtained in soxhlet
extractor with organic solvents and five fractions were used by flash filtration chromatography. The bioassays were performed in
200mL glass and 24-well plates, using 1674 mollusks in the bioassays. The results showed that the 500mg/L beaker tests obtained
100% mortality rate for the crude extracts in hexane and dichloromethane and 93% for chloroform extract. In plaque tests, the
dichloromethane extracts the lowest CL90 = 318mg/L. The mortality rate with the fractions was 100% at a concentration of 300mg/L.
It was concluded that the tests performed on cups and plates showed significant results. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Mestrado em Ciências Biológicas e Biotecnologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Politécnica de Saúde Joaquim Venâncio. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Schistosomíasis | pt_BR |
| Subject | Plectranthus grandis | pt_BR |
| Subject | Natural products | pt_BR |
