| Author | Rego, Natalia | |
| Author | Salazar, Cecilia | |
| Author | Paz, Mercedez | |
| Author | Costábile, Alicia | |
| Author | Fajardo, Alvaro | |
| Author | Ferrés, Ignacio | |
| Author | Perbolianachis, Paula | |
| Author | Fernández-Calero, Tamara | |
| Author | Noya, Veronica | |
| Author | Machado, Matias R. | |
| Author | Brandes, Mariana | |
| Author | Arce, Rodrigo | |
| Author | Arleo, Mailen | |
| Author | Possi, Tania | |
| Author | Reyes, Natalia | |
| Author | Bentancor, Maria Noel | |
| Author | Lizasoain, Andrés | |
| Author | Bortagaray, Viviana | |
| Author | Moller, Ana | |
| Author | Chappos, Odhille | |
| Author | Nin, Nicolas | |
| Author | Hurtado, Javier | |
| Author | Duquía, Melissa | |
| Author | González, Maria Belén | |
| Author | Griffero, Luciana | |
| Author | Méndez, Mauricio | |
| Author | Techera, Maria Pía | |
| Author | Zanetti, Juan | |
| Author | Pereira, Emiliano | |
| Author | Rivera, Bernardina | |
| Author | Maidana, Matías | |
| Author | Alonso, Martina | |
| Author | Smircich, Pablo | |
| Author | Arantes, Ighor | |
| Author | Mir, Daiana | |
| Author | Alonso, Ceclia | |
| Author | Medina, Julio | |
| Author | Albornoz, Henry | |
| Author | Colina, Rodney | |
| Author | Bello, Gonzalo | |
| Author | Moreno, Pilar | |
| Author | Moratorio, Gonzalo | |
| Author | Iraola, Gregorio | |
| Author | Spangenberg, Lucía | |
| Access date | 2021-12-10T18:37:04Z | |
| Available date | 2021-12-10T18:37:04Z | |
| Document date | 2021 | |
| Citation | REGO, Natalia et al. Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay. Viruses, v. 13, 1801, p. 1 - 16, Sept. 2021. | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50305 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Subject in Portuguese | Espigão | pt_BR |
| Subject in Portuguese | Filogeografia | pt_BR |
| Subject in Portuguese | Filogenética | pt_BR |
| Subject in Portuguese | Uruguai | pt_BR |
| Title | Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay | pt_BR |
| Type | Article | |
| DOI | 10.3390/v13091801 | |
| Abstract | Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2
pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased.
Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November
2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic
wave in Uruguay (December 2020–February 2021) was a B.1.1.28 sublineage carrying Spike mutations
Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around
November 2020, in Montevideo, Uruguay’s capital department, and rapidly spread to other departments,
with evidence of further local transmission clusters; it also spread sporadically to the USA
and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence
of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1/S2 boundary
suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although
P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since
April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of
worldwide interest. | pt_BR |
| Affilliation | Bioinformatics Unit, Institut Pasteur de Montevideo. Montevideo 11400, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Genómica Microbiana, Institut Pasteur Montevideo. Montevideo. Uruguay / Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Montevideo. Uruguay. | pt_BR |
| Affilliation | Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Montevideo. Uruguay. | pt_BR |
| Affilliation | Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Montevideo. Uruguay / Laboratorio de Virología Molecular, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay / Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo. Montevideo, Uruguay / Sección Bioquímica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Virología Molecular, Facultad de Ciencias, Universidad de la República, Montevideo / Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo, Montevideo, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Genómica Microbiana, Institut Pasteur Montevideo. Montevideo. Uruguay / Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Montevideo. Uruguay. | pt_BR |
| Affilliation | Laboratorio de Virología Molecular, Facultad de Ciencias, Universidad de la República, Montevideo / Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo, Montevideo, Uruguay. | pt_BR |
| Affilliation | Bioinformatics Unit, Institut Pasteur de Montevideo. Montevideo 11400, Uruguay / Department of Exact and Natural Sciences, Universidad Católica del Uruguay, Montevideo, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Biología Molecular, Sanatorio Americano. Montevideo, Uruguay. | pt_BR |
| Affilliation | Protein Engineering, Institut Pasteur de Montevideo. Montevideo, Uruguay. | pt_BR |
| Affilliation | Bioinformatics Unit, Institut Pasteur de Montevideo. Montevideo 11400, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Virología Molecular, Facultad de Ciencias, Universidad de la República, Montevideo / Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo, Montevideo, Uruguay / Laboratorio de Biología Molecular, Sanatorio Americano, Montevideo. | pt_BR |
| Affilliation | Laboratorio de Biología Molecular, Sanatorio Americano, Montevideo. | pt_BR |
| Affilliation | Laboratorio de Biología Molecular, Sanatorio Americano, Montevideo. | pt_BR |
| Affilliation | Laboratorio de Biología Molecular, Sanatorio Americano, Montevideo. | pt_BR |
| Affilliation | Laboratorio de Biología Molecular, Sanatorio Americano, Montevideo. | pt_BR |
| Affilliation | Laboratorio de Virología Molecular, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República. Salto 50000, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Virología Molecular, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República. Salto 50000, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Virología Molecular, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República. Salto 50000, Uruguay. | pt_BR |
| Affilliation | Centro Universitario Regional Este, Universidad de la República. Rocha 27000, Uruguay. | pt_BR |
| Affilliation | Unidad de Cuidados Intensivos, Hospital Español “Juan J. Crottogini”. Montevideo, Uruguay. | pt_BR |
| Affilliation | Unidad de Cuidados Intensivos, Hospital Español “Juan J. Crottogini”. Montevideo, Uruguay. | pt_BR |
| Affilliation | Centro Universitario Regional Este, Universidad de la República, Rocha 27000, Uruguay. | pt_BR |
| Affilliation | Centro Universitario Regional Este, Universidad de la República, Rocha 27000, Uruguay. | pt_BR |
| Affilliation | Centro Universitario Regional Este, Universidad de la República, Rocha 27000, Uruguay. | pt_BR |
| Affilliation | Centro Universitario Regional Este, Universidad de la República, Rocha 27000, Uruguay. | pt_BR |
| Affilliation | Centro Universitario Regional Este, Universidad de la República, Rocha 27000, Uruguay. | pt_BR |
| Affilliation | Centro Universitario Regional Este, Universidad de la República, Rocha 27000, Uruguay. | pt_BR |
| Affilliation | Centro Universitario Regional Este, Universidad de la República, Rocha 27000, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Diagnóstico Molecular. Institut Pasteur de Montevideo. Montevideo, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Diagnóstico Molecular. Institut Pasteur de Montevideo. Montevideo, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Diagnóstico Molecular. Institut Pasteur de Montevideo. Montevideo, Uruguay. | pt_BR |
| Affilliation | Bioinformatics Laboratory, Department of Genomics, Instituto de Investigaciones Biológicas Clemente Estable, MEC, Montevideo, Uruguay / Laboratory of Molecular Interactions, Facultad de Ciencias, UdelaR, Montevideo, Uruguay, | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Unidad de Genómica y Bioinformática, Departamento de Ciencias Biológicas, Centro Universitario Regional Litoral Norte, Universidad de la República, Salto 50000, Uruguay. | pt_BR |
| Affilliation | Centro Universitario Regional Este, Universidad de la República, Rocha 27000, Uruguay. | pt_BR |
| Affilliation | Cátedra de Enfermedades Infecciosas, Facultad de Medicina, Universidad de la República, Montevideo 11300, Uruguay / Dirección General de Salud, Ministerio de Salud Pública, Montevideo, Uruguay. | pt_BR |
| Affilliation | Cátedra de Enfermedades Infecciosas, Facultad de Medicina, Universidad de la República, Montevideo 11300, Uruguay / Dirección General de Salud, Ministerio de Salud Pública, Montevideo, Uruguay. | pt_BR |
| Affilliation | Laboratorio de Virología Molecular, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Salto 50000, Uruguay. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Montevideo. Uruguay / Laboratorio de Virología Molecular, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay / Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo. Montevideo, Uruguay / Sección Bioquímica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay. | pt_BR |
| Affilliation | Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Montevideo. Uruguay / Laboratorio de Virología Molecular, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay / Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo. Montevideo, Uruguay / Sección Bioquímica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay. | pt_BR |
| Affilliation | Centro de Innovación en Vigilancia Epidemiológica, Institut Pasteur Montevideo, Montevideo. Uruguay / Laboratorio de Virología Molecular, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay / Laboratorio de Evolución Experimental de Virus, Institut Pasteur de Montevideo. Montevideo, Uruguay / Sección Bioquímica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay / Center for Integrative Biology, Universidad Mayor, Santiago de Chile 8580745, Chile / Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. | pt_BR |
| Affilliation | Bioinformatics Unit, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay / Department of Informatics and Computer Science, Universidad Católica del Uruguay, Montevideo 11600, Uruguay. | pt_BR |
| Subject | SARS-CoV-2 | pt_BR |
| Subject | B.1.1.28 | pt_BR |
| Subject | Spike | pt_BR |
| Subject | Q675H | pt_BR |
| Subject | Q677H | pt_BR |
| Subject | Uruguay | pt_BR |
| Subject | Phylogeography | pt_BR |
| Subject | Phylogenetics | pt_BR |
