| Author | Pacheco, Paulo A. F. | |
| Author | Faria, Robson X. | |
| Access date | 2021-12-12T14:30:11Z | |
| Available date | 2021-12-12T14:30:11Z | |
| Document date | 2020 | |
| Citation | PACHECO, Paulo A. F. ; FARIA, Robson X. The potential involvement of P2X7 receptor in COVID-19 pathogenesis: A new therapeutic target? Scandinavian Journal of Immunology, v. 93, n. 2, p. 1-9, Aug. 2020. | pt_BR |
| ISSN | 0300-9475 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50315 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | Envolvimento portencial | pt_BR |
| Subject in Portuguese | Receptor P2X7 | pt_BR |
| Subject in Portuguese | Patogênese | pt_BR |
| Subject in Portuguese | Alvo terapêutico | pt_BR |
| Title | The potential involvement of P2X7 receptor in COVID-19 pathogenesis: A new therapeutic target? | pt_BR |
| Type | Article | |
| DOI | 10.1111/sji.12960 | |
| Abstract | Coronavirus disease 2019 (COVID-19) pathogenesis remains under investigation. Growing evidence indicates the establishment of a hyperinflammatory response, characterized by sustained production of cytokines, such as IL-1β. The release and maturation of this cytokine are dependent on the activation of a catalytic multiprotein complex, known as “inflammasome”. The most investigated is the NLRP3 inflammasome, which can be activated by various stimuli, such as the recognition of extracellular ATP by the P2X7 receptor. Based on the recent literature, we present evidence that supports the idea that the P2X7R/NLRP3 axis may be involved in the immune dysregulation caused by the SARS-CoV-2 infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e outras Protozooses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e outras Protozooses. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | P2X7 receptor | pt_BR |
| Subject | Pathogenesis | pt_BR |
| Subject | Potential involvement | pt_BR |
| Subject | Therapeutic target | pt_BR |
| Subject | COVID-19 | pt_BR |
