| Author | Torres, Thiago S. | |
| Author | Harrison, Linda J. | |
| Author | La Rosa, Alberto M. | |
| Author | Zheng, Lu | |
| Author | Cardoso, Sandra W. | |
| Author | Ulaya, Godwin | |
| Author | Akoojee, Nazim | |
| Author | Kadam, Dileep | |
| Author | Collier, Ann C. | |
| Author | Hughes, Michael D. | |
| Access date | 2021-12-21T00:04:08Z | |
| Available date | 2021-12-21T00:04:08Z | |
| Document date | 2021 | |
| Citation | TORRES, Thiago S. et al. Poor quality of life and incomplete self-reported adherence predict second-line ART virological failure in resource-limited settings. AIDS Care, v. 33, n. 10, p. 1340-1349, Oct. 2021. | pt_BR |
| ISSN | 0954-0121 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50494 | |
| Description | AIDS Clinical Trials Group (ACTG) A5273 Study Group. | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | open access | pt_BR |
| Title | Poor quality of life and incomplete self-reported adherence predict second-line ART virological failure in resource-limited settings | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1080/09540121.2021.1874275 | |
| Abstract | We evaluated health-related quality of life (QoL) and self-reported incomplete adherence as predictors of early second-line antiretroviral (ART) virological failure (VF). ACTG A5273 study participants completed the ACTG SF-21 measure which has 8 QoL domains. We used exact logistic regression to assess the association of QoL at baseline and week 4 with early VF adjusted for self-reported adherence. Of 500 individuals (51% women, median age 39 years) in this analysis, 79% and 75% self-reported complete adherence (no missing doses in the past month) at weeks 4 and 24, respectively. Early VF was experienced by 7% and more common among those who self-reported incomplete adherence. Participants with low week 4 QoL scores had higher rates of early VF than participants with high scores. After adjusting for self-reported adherence at week 4, VL and CD4 at baseline, cognitive functioning, pain and mental health domains were significantly associated with subsequent early VF. In this post-hoc analysis, poorer QoL adds to self-reported incomplete adherence after 4 weeks of second-line ART in predicting VF at week 24. Evaluation is needed to assess whether individuals with poorer QoL might be targeted for greater support to reduce risk of VF. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil / Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA. | pt_BR |
| Affilliation | Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA. | pt_BR |
| Affilliation | Asociación Civil Impacta Salud y Educación. Lima, Peru. | pt_BR |
| Affilliation | Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Blantyre CRS. Blantyre, Malawi. | pt_BR |
| Affilliation | Perinatal HIV Research Unit. Soweto, South Africa. | pt_BR |
| Affilliation | Byramjee-Jeejeebhoy Medical College. Pune, Maharashtra, India. | pt_BR |
| Affilliation | University of Washington School of Medicine. Department of Medicine. Seattle, WA, USA. | pt_BR |
| Affilliation | Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Adherence | pt_BR |
| Subject | Antiretroviral therapy | pt_BR |
| Subject | Quality of life | pt_BR |
| Subject | Second-line therapy | pt_BR |
| Subject | Virological failure | pt_BR |
