| Author | Williams-Blangero, Sarah | |
| Author | Berg, John L. Vande | |
| Author | Subedi, Janardan | |
| Author | Jha, Bharat | |
| Author | Oliveira, Rodrigo Corrêa de | |
| Author | Blangero, John | |
| Access date | 2021-12-28T16:06:58Z | |
| Available date | 2021-12-28T16:06:58Z | |
| Document date | 2008 | |
| Citation | WILLIAMS-BLANGERO, Sarah et al. Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. J Infect Dis, v. 197, n. 1, p. 66-71, 2008 . doi: 10.1086/524060. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50545 | |
| Sponsorship | NATIONAL INSTITUTES OF HEALTH | pt_BR |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | verminoses | pt_BR |
| Subject in Portuguese | Ascaridis lombricoides | pt_BR |
| Title | Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides | pt_BR |
| Type | Article | |
| DOI | 10.1086/524060 | |
| Abstract | A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P =.013), 8 (LOD score, 3.03; genomewide P =.031), and 11 (LOD score, 3.19; genomewide P =.020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P =.067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13 | pt_BR |
| Affilliation | Department of Genetics.Southwest Foundation for Biomedical Research. | pt_BR |
| Affilliation | Department of Genetics.Southwest Foundation for Biomedical Research/Southwest National Primate Research Center. San Antonio, Texas | pt_BR |
| Affilliation | Department of Sociology and Gerontology. Miami University. Oxford, Ohio | pt_BR |
| Affilliation | Tribhuvan University Institute of Medicine Kathmandu. Nepal | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratory of Cellular and Molecular Immunology. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Department of Genetics. Southwest Foundation for Biomedical Research. | pt_BR |
