| Author | Moraes, Vanessa Silva | |
| Author | Ferreira, Jaqueline Maria Siqueira | |
| Author | Coelho, Paulo Marcos Zech | |
| Author | Grenfell, Rafaella Fortini Queiroz | |
| Access date | 2021-12-30T13:06:45Z | |
| Available date | 2021-12-30T13:06:45Z | |
| Document date | 2014 | |
| Citation | MORAES, Vanessa Silva et al. Biomarkers for schistosomiasis: Towards an integrative view of the search for an effective diagnosis. Acta Tropica, v.132, p. 75-79, 2014. doi.org/10.1016/j.actatropica.2013.12.024 | pt_BR |
| ISSN | 0001-706X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50582 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Biomarkers for schistosomiasis: Towards an integrative view of the search for an effective diagnosis | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2013.12.024 | |
| Abstract | Human schistosomiasis, caused mainly by Schistosoma mansoni, S. japonicum, and S. hematobium, remains a prevalent and serious parasitic disease worldwide. Although it is a debilitating disease, a lack of sensitive methods for the precise diagnosis of active infection cases is important to prevent morbidity. The optimization of new diagnostic approaches may be accomplished by the selection of specific markers. In that manner, markers can be satisfactorily used for detection of different phases of infection, as acute and chronic phases, pre-patent and post-patent phases and after chemotherapy, improving the efficiency of methods. For that purpose, proteomics and glycomics analyses have been performed in schistosomes, in particular S. mansoni, using powerful high-throughput methodologies. These investigations have not only chartered protein, o-glycan and n-glycan profiles across developmental stages within mammalian host, but are also leading to the characterization of features of the surface tegument, the eggshell and excretory-secretory proteomes of schistosomes. (C) 2014 Elsevier B.V. All rights reserved | pt_BR |
| Affilliation | Laboratory of Schistosomiasis. Monoclonal Antibody Facility. Research Center Rene Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/Laboratory of Microbiology. Universidade Federal de São João Del-Rei. Divinópolis, MG, Brazil | pt_BR |
| Affilliation | Laboratory of Microbiology. Universidade Federal de São João Del-Rei. Divinópolis, MG, Brazil | pt_BR |
| Affilliation | Laboratory of Schistosomiasis. Monoclonal Antibody Facility. Research Center Rene Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Laboratory of Schistosomiasis. Monoclonal Antibody Facility. Research Center Rene Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Biomarkers | pt_BR |
| Subject | Diagnosis | pt_BR |
| Subject | Schistosomiasis mansoni | pt_BR |
| Subject | Adult worm | pt_BR |
| Subject | Schistossomula | pt_BR |
| Subject | Egg | pt_BR |
