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https://www.arca.fiocruz.br/handle/icict/50614
TWO-DOSE CHADOX1 NCOV-19 VACCINE PROTECTION AGAINST COVID-19 HOSPITAL ADMISSIONS AND DEATHS OVER TIME: A RETROSPECTIVE, POPULATION-BASED COHORT STUDY IN SCOTLAND AND BRAZIL
(Prof S V Katikireddi PhD, S Amele PhD); Public Health Scotland, Glasgow, UK (Prof S V Katikireddi, Prof C Robertson PhD, B Taylor PhD, J McMenamin MBChB, E Moore PhD); Instituto Gonçalo Moniz, Fiocruz, Bahia, Brazil (T Cerqueira-Silva, R Flores-Ortiz PhD, Prof M L Barreto MD, V d A Oliveira MD, Prof M Barral-Netto MD, Prof V Boaventura MD, Prof M Barral-Netto); Universidade Federal de Bahia, Salvador, Bahia, Brazil (T Cerqueira-Silva, Prof V Boaventura, Prof M L Barreto, Prof M Barral-Netto, V d A Oliveira); Usher Institute, University of Edinburgh, Edinburgh, UK (E Vasileiou PhD, A B Docherty PhD, Prof I Rudan PhD, S A Shah PhD, T Shi PhD, Prof C R Simpson PhD, Prof A Sheikh MD); Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK (Prof C Robertson, J Pan PhD); Departamento de Epidemiologia of Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil (Prof G L Werneck PhD); School of Medicine, University of St Andrews, St Andrews, UK (U Agrawal PhD, Prof C McCowan PhD); Academic Primary Care, University of Aberdeen, Aberdeen, UK (Prof L D Ritchie MD); School of Health, Wellington Faculty of Health, Victoria University of Wellington, New Zealand (Prof C R Simpson).
Author
Katikireddi, Srinivasa Vittal
Silva, Thiago Cerqueira
Vasileiou, Eleftheria
Robertson, Chris
Amele, Sarah
Pan, Jiafeng
Taylor, Bob
Boaventura, Viviane
Werneck, Guilherme Loureiro
Ortiz, Renzo Flores
Agrawal, Utkarsh
Docherty, Annemarie B.
McCowan, Colin
McMenamin, Jim
Moore, Emily
Ritchie, Lewis D.
Rudan, Igor
Shah, Syed Ahmar
Shi, Ting
Simpson, Colin R.
Barreto, Mauricio Lima
Oliveira, Vinicius de Araujo
Barral Netto, Manoel
Sheikh, Aziz
Silva, Thiago Cerqueira
Vasileiou, Eleftheria
Robertson, Chris
Amele, Sarah
Pan, Jiafeng
Taylor, Bob
Boaventura, Viviane
Werneck, Guilherme Loureiro
Ortiz, Renzo Flores
Agrawal, Utkarsh
Docherty, Annemarie B.
McCowan, Colin
McMenamin, Jim
Moore, Emily
Ritchie, Lewis D.
Rudan, Igor
Shah, Syed Ahmar
Shi, Ting
Simpson, Colin R.
Barreto, Mauricio Lima
Oliveira, Vinicius de Araujo
Barral Netto, Manoel
Sheikh, Aziz
Affilliation
Múltipla - Ver em Notas.
Abstract
Background Reports suggest that COVID-19 vaccine effectiveness is decreasing, but whether this reflects waning or
new SARS-CoV-2 variants—especially delta (B.1.617.2)—is unclear. We investigated the association between time
since two doses of ChAdOx1 nCoV-19 vaccine and risk of severe COVID-19 outcomes in Scotland (where delta was
dominant), with comparative analyses in Brazil (where delta was uncommon).
Methods In this retrospective, population-based cohort study in Brazil and Scotland, we linked national databases
from the EAVE II study in Scotland; and the COVID-19 Vaccination Campaign, Acute Respiratory Infection Suspected
Cases, and Severe Acute Respiratory Infection/Illness datasets in Brazil) for vaccination, laboratory testing, clinical,
and mortality data. We defined cohorts of adults (aged ≥18 years) who received two doses of ChAdOx1 nCoV-19 and
compared rates of severe COVID-19 outcomes (ie, COVID-19 hospital admission or death) across fortnightly periods,
relative to 2–3 weeks after the second dose. Entry to the Scotland cohort started from May 19, 2021, and entry to the
Brazil cohort started from Jan 18, 2021. Follow-up in both cohorts was until Oct 25, 2021. Poisson regression was used
to estimate rate ratios (RRs) and vaccine effectiveness, with 95% CIs.
Publisher
Elsevier
Citation
KATIKIREDDI, Srinivasa Vittal et al. Two-dose ChAdOx1 nCoV-19 vaccine protection against COVID-19 hospital admissions and deaths over time: a retrospective, population-based cohort study in Scotland and Brazil. The Lancet, v. 399, p. 25-32, Jan. 1, 2022.DOI
10.1016/S0140-6736(21)02754-9ISSN
0140-6736Notes
Viviane Boaventura, Thiago Cerqueira-Silva, Renzo Flores-Ortiz, Mauricio L. Barreto, Vinicius de Araujo Oliveira, Manoel Barral-Netto. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.(Prof S V Katikireddi PhD, S Amele PhD); Public Health Scotland, Glasgow, UK (Prof S V Katikireddi, Prof C Robertson PhD, B Taylor PhD, J McMenamin MBChB, E Moore PhD); Instituto Gonçalo Moniz, Fiocruz, Bahia, Brazil (T Cerqueira-Silva, R Flores-Ortiz PhD, Prof M L Barreto MD, V d A Oliveira MD, Prof M Barral-Netto MD, Prof V Boaventura MD, Prof M Barral-Netto); Universidade Federal de Bahia, Salvador, Bahia, Brazil (T Cerqueira-Silva, Prof V Boaventura, Prof M L Barreto, Prof M Barral-Netto, V d A Oliveira); Usher Institute, University of Edinburgh, Edinburgh, UK (E Vasileiou PhD, A B Docherty PhD, Prof I Rudan PhD, S A Shah PhD, T Shi PhD, Prof C R Simpson PhD, Prof A Sheikh MD); Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK (Prof C Robertson, J Pan PhD); Departamento de Epidemiologia of Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil (Prof G L Werneck PhD); School of Medicine, University of St Andrews, St Andrews, UK (U Agrawal PhD, Prof C McCowan PhD); Academic Primary Care, University of Aberdeen, Aberdeen, UK (Prof L D Ritchie MD); School of Health, Wellington Faculty of Health, Victoria University of Wellington, New Zealand (Prof C R Simpson).
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