| Author | Nonaka, Carolina Kymie Vasques | |
| Author | Gräf, Tiago | |
| Author | Barcia, Camila Araújo de Lorenzo | |
| Author | Costa, Vanessa Ferreira | |
| Author | Oliveira, Janderson Lopes de | |
| Author | Passos, Rogério da Hora | |
| Author | Bastos, Iasmin Nogueira | |
| Author | Santana, Maria Clara Brito de | |
| Author | Santos, Ian Marinho | |
| Author | Sousa, Karoline Almeida Felix de | |
| Author | Weber, Thamires Gomes Lopes | |
| Author | Siqueira, Isadora Cristina de | |
| Author | Rocha, Clarissa Araújo Gurgel | |
| Author | Mendes, Ana Verena Almeida | |
| Author | Souza, Bruno Solano de Freitas | |
| Access date | 2022-01-07T21:07:02Z | |
| Available date | 2022-01-07T21:07:02Z | |
| Document date | 2021 | |
| Citation | NONAKA, Carolina Kymie Vasques et al. SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, northeast Brazil, February 2021. International Journal of Infectious Diseases, v. 111, p. 47-54, 2021. | pt_BR |
| ISSN | 1201-9712 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50679 | |
| Sponsorship | This study was funded by CNPq, Inova Fiocruz, the Serrapilheira Institute, and the D’Or Institute for Research and Education. Ethics statement This study was reviewed by local IRBs and received ethical approval by the National Committee for Ethics on Research (CONEP; CAAE: 29496920.8.0000.5262, 46821621.5.0000.0048 and 3.980.128 /2020). All sampled patients have provided written informed consent. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Previous version | https://www.arca.fiocruz.br/handle/icict/48692 | pt_BR |
| Rights | open access | pt_BR |
| Title | SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021 | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.ijid.2021.08.003 | |
| Abstract | Objectives: To evaluate changes in the characteristics of patients with coronavirus disease 2019 (COVID-19) after the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) P.1 (Gamma), by comparing the clinical, demographic, and laboratory profiles of patients hospitalized during the first (May to July 2020) and second (December 2020 to February 2021) pandemic waves. Methods: Data were collected from the records of COVID-19 patients (n = 4164) admitted to a single hospital in Salvador, Northeast Brazil. SARS-CoV-2 genome sequencing was performed on nasopharyngeal swab samples from 12 patients aged <60 years admitted to the intensive care unit (ICU) in February 2021. Results: Between June 2020 and February 2021, the median age of patients admitted to the ICU decreased from 66 to 58 years (P < 0.05). This was accompanied by an increased proportion of patients without comorbidities (15.32% vs 32.20%, P < 0.0001). A significant reduction in the cycle threshold values of SARS-CoV-2 RT-PCR tests was observed in the second wave (P < 0.0001). Sequencing analysis detected lineage Gamma in all 12 ICU patients sampled in February 2021. Conclusions: The results of this study demonstrated an increased proportion of younger adults without comorbidities with severe disease during the second COVID-19 wave, shortly after the confirmation of local Gamma circulation. | pt_BR |
| Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D'Or Institute for Research and Education (IDOR). Salvador, BA, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil. | pt_BR |
| Affilliation | São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil. | pt_BR |
| Affilliation | São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil. | pt_BR |
| Affilliation | São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | São Rafael Hospital. Clinical Laboratory. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil. | pt_BR |
| Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Subject | COVID-19 | pt_BR |
| Subject | SARS-CoV-2 | pt_BR |
| Subject | Variants of concern | pt_BR |
| Subject | P.1 | pt_BR |
| Subject | Gamma | pt_BR |
