| Author | Hampson, Alan | |
| Author | Barr, Ian | |
| Author | Cox, Nancy | |
| Author | Donis, Ruben O. | |
| Author | Siddhivinayak, Hirve | |
| Author | Jernigan, Daniel | |
| Author | Katz, Jacqueline | |
| Author | McCauley, John | |
| Author | Motta, Fernando | |
| Author | Odagiri, Takato | |
| Author | Tam, John S. | |
| Author | Waddell, Anthony | |
| Author | Webby, Richard | |
| Author | Ziegler, Thedi | |
| Author | Zhang, Wenqing | |
| Access date | 2022-01-14T14:55:08Z | |
| Available date | 2022-01-14T14:55:08Z | |
| Document date | 2017 | |
| Citation | HAMPSON, Alan et al. Improving the selection and development of influenza vaccine viruses – Report of a WHO informal consultation on improving influenza vaccine virus selection, Hong Kong SAR, China, 18–20 November 2015. Vaccine, v. 35, p. 1104-1109, Jan. 2017. | pt_BR |
| ISSN | 0264-410X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50756 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vacinas contra a gripe | pt_BR |
| Subject in Portuguese | Vigilância | pt_BR |
| Subject in Portuguese | Deriva antigênica | pt_BR |
| Subject in Portuguese | Influenza pandémica | pt_BR |
| Title | Improving the selection and development of influenza vaccine viruses – Report of a WHO informal consultation on improving influenza vaccine virus selection, Hong Kong SAR, China, 18–20 November 2015 | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.vaccine.2017.01.018 | |
| Abstract | Since 2010 the WHO has held a series of informal consultations to explore ways of improving the currently
highly complex and time-pressured influenza vaccine virus selection and development process.
In November 2015 experts from around the world met to review the current status of efforts in this field.
Discussion topics included strengthening influenza surveillance activities to increase the availability of
candidate vaccine viruses and improve the extent, timeliness and quality of surveillance data.
Consideration was also given to the development and potential application of newer laboratory assays
to better characterize candidate vaccine viruses, the potential importance of antibodies directed against
influenza virus neuraminidase, and the role of vaccine effectiveness studies. Advances in next generation
sequencing and whole genome sequencing of influenza viruses were also discussed, along with associated
developments in synthetic genomics technologies, evolutionary analysis and predictive mathematical
modelling.
Discussions were also held on the late emergence of an antigenic variant influenza A(H3N2) virus in
mid-2014 that could not be incorporated in time into the 2014–15 northern hemisphere vaccine.
There was broad recognition that given the current highly constrained influenza vaccine development
and production timeline it would remain impossible to incorporate any variant virus which emerged significantly
long after the relevant WHO biannual influenza vaccine composition meetings. Discussions
were also held on the development of pandemic and broadly protective vaccines, and on associated regulatory
and manufacturing requirements and constraints.
With increasing awareness of the health and economic burdens caused by seasonal influenza, the everpresent
threat posed by zoonotic influenza viruses, and the significant impact of the 2014–15 northern
hemisphere seasonal influenza vaccine mismatch, this consultation provided a very timely opportunity to share developments and exchange views. In all areas, a renewed and strengthened emphasis was
placed on developing concrete and measurable actions and identifying the key stakeholders responsible
for their implementation. | pt_BR |
| Affilliation | Interflu Pty Ltd, Victoria, Australia. | pt_BR |
| Affilliation | Victorian Infectious Diseases Reference Laboratory (VIDRL). Melbourne, Australia. | pt_BR |
| Affilliation | Centers for Disease Control and Prevention (CDC). Atlanta, USA. | pt_BR |
| Affilliation | Biomedical Advanced Research and Development Authority (BARDA), ASPR, US Department of Health and Human Services. Washington DC, USA. | pt_BR |
| Affilliation | Global Influenza Programme, World Health Organization (WHO). Geneva, Switzerland. | pt_BR |
| Affilliation | Centers for Disease Control and Prevention (CDC). Atlanta, USA. | pt_BR |
| Affilliation | Centers for Disease Control and Prevention (CDC). Atlanta, USA. | pt_BR |
| Affilliation | The Francis Crick Institute. London, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | National Institute of Infectious Diseases. Tokyo, Japan. | pt_BR |
| Affilliation | The Hong Kong Polytechnic University, Hong Kong Special Administrative Region. Hong Kong. | pt_BR |
| Affilliation | Freelance writer and editor. Stanley, UK. | pt_BR |
| Affilliation | St Jude Childrens Research Hospital. Memphis, USA. | pt_BR |
| Affilliation | Global Influenza Programme, World Health Organization (WHO). Geneva, Switzerland. | pt_BR |
| Affilliation | Global Influenza Programme, World Health Organization (WHO). Geneva, Switzerland. | pt_BR |
| Subject | Influenza vaccines | pt_BR |
| Subject | Surveillance | pt_BR |
| Subject | Antigenic drift | pt_BR |
| Subject | Pandemic influenza | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
