| Author | Butera, Yvan | |
| Author | Mukantwari, Enatha | |
| Author | Artesi, Maria | |
| Author | Umuringa, Jeanne d´arc | |
| Author | O`Toole, Áine Niamh | |
| Author | Hill, Verity | |
| Author | Rooke, Stefan | |
| Author | Hong, Samuel Leandro | |
| Author | Dellicou, Simon | |
| Author | Majyambere, Onesphore | |
| Author | Bontems, Sebastien | |
| Author | Boujemla, Bouchra | |
| Author | Quick, Josh | |
| Author | Resende, Paola Cristina | |
| Author | Loman, NIck | |
| Author | Umumararungu, Esperance | |
| Author | Kabanda, Alice | |
| Author | Murindahabi, Marylin Milumbu | |
| Author | Tuyisenge, Patrick | |
| Author | Gashegu, Misbah | |
| Author | Rwabihama, Jean Paul | |
| Author | Sindayiheba, Reuben | |
| Author | Gikic, Djordje | |
| Author | Souopgui, Jacob | |
| Author | Ndifon, Wilfred | |
| Author | Rutayisire, Robert | |
| Author | Gatare, Swaibu | |
| Author | Mpunga, Tharcisse | |
| Author | Ngamije, Daniel | |
| Author | Bours, Vincent | |
| Author | Rambaut, Andrew | |
| Author | Nsanzimana, Sabin | |
| Author | Baele, Guy | |
| Author | Durkin, Keith | |
| Author | Mutesa, Leon | |
| Author | Rujeni, Nadine | |
| Access date | 2022-01-17T18:47:33Z | |
| Available date | 2022-01-17T18:47:33Z | |
| Document date | 2021 | |
| Citation | BUTERA, Yvan et al. Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity. Nature Communications, v. 12, 5705, p. 1-11, 2021. | pt_BR |
| ISSN | 2041-1723 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50789 | |
| Language | eng | pt_BR |
| Publisher | Nature | pt_BR |
| Rights | open access | |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Subject in Portuguese | Sequenciamento genômico | pt_BR |
| Subject in Portuguese | Ruanda, África | pt_BR |
| Subject in Portuguese | Importância dos viajantes | pt_BR |
| Subject in Portuguese | Com diversidade de linhagem | pt_BR |
| Subject in Portuguese | Taxas de transmissão | pt_BR |
| Title | Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41467-021-25985-7 | |
| Abstract | COVID-19 transmission rates are often linked to locally circulating strains of SARS-CoV-2.
Here we describe 203 SARS-CoV-2 whole genome sequences analyzed from strains circulating
in Rwanda from May 2020 to February 2021. In particular, we report a shift in variant
distribution towards the emerging sub-lineage A.23.1 that is currently dominating. Furthermore,
we report the detection of the first Rwandan cases of the B.1.1.7 and B.1.351 variants of
concern among incoming travelers tested at Kigali International Airport. To assess the
importance of viral introductions from neighboring countries and local transmission, we
exploit available individual travel history metadata to inform spatio-temporal phylogeographic
inference, enabling us to take into account infections from unsampled locations. We uncover
an important role of neighboring countries in seeding introductions into Rwanda, including
those from which no genomic sequences were available. Our results highlight the importance
of systematic genomic surveillance and regional collaborations for a durable response
towards combating COVID-19. | pt_BR |
| Affilliation | Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda. Kigali, Rwanda / Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health. Kigali, Rwanda / Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium. | pt_BR |
| Affilliation | National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda. | pt_BR |
| Affilliation | Laboratory of Human Genetics, GIGA Research Institute. Liège, Belgium. | pt_BR |
| Affilliation | National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda. | pt_BR |
| Affilliation | Institute of Evolutionary Biology, University of Edinburgh. Edinburgh, Scotland. | pt_BR |
| Affilliation | Institute of Evolutionary Biology, University of Edinburgh. Edinburgh, Scotland. | pt_BR |
| Affilliation | Institute of Evolutionary Biology, University of Edinburgh. Edinburgh, Scotland. | pt_BR |
| Affilliation | Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven. Leuven, Belgium. | pt_BR |
| Affilliation | Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven. Leuven, Belgium / Spatial Epidemiology Laboratory, Université Libre de Bruxelles. Brussels, Belgium. | pt_BR |
| Affilliation | National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda. | pt_BR |
| Affilliation | Department of Clinical Microbiology, University Hospital of Liège., Liège, Belgium. | pt_BR |
| Affilliation | Laboratory of Human Genetics, GIGA Research Institute. Liège, Belgium. | pt_BR |
| Affilliation | University of Birmingham. Birmingham, England. | pt_BR |
| Affilliation | University College London. London, England / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Birmingham. Birmingham, England. | pt_BR |
| Affilliation | National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda. | pt_BR |
| Affilliation | National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda. | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda / School of Science, College of Science and Technology, University of Rwanda. Kigali, Rwanda. | pt_BR |
| Affilliation | National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda. | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda. | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda. | pt_BR |
| Affilliation | National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda. | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda. | pt_BR |
| Affilliation | Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda / Department of Molecular Biology, Institute of Biology and Molecular Medicine, IBMM, Université Libre de, Bruxelles. Gosselies, Belgium. | pt_BR |
| Affilliation | African Institute for Mathematical Sciences. Kigali, Rwanda. | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda / National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda. | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda / National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda. | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda | pt_BR |
| Affilliation | Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium / Department of Human Genetics, University Hospital of Liège, Liège, Belgium. | pt_BR |
| Affilliation | Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland. | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health. Kigali, Rwanda. | pt_BR |
| Affilliation | Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven. Leuven, Belgium. | pt_BR |
| Affilliation | Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium. | pt_BR |
| Affilliation | Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda / Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda. | pt_BR |
| Affilliation | Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda / Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven, Leuven, Belgium. | pt_BR |
| Subject | SARS-CoV-2 | pt_BR |
| Subject | Rwanda | pt_BR |
| Subject | Genomic sequencing | pt_BR |
| Subject | Importance of incoming travelers | pt_BR |
| Subject | Lineage diversity | pt_BR |
| Subject | Transmission rates | pt_BR |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
