Author | Salles, Paula Ferreira | |
Author | Silva, Daiana Souza Perce da | |
Author | Rossi, Atila Duque | |
Author | Raposo, Luisa Riehl | |
Author | Ramirez, Aina Danaisa Ramirez | |
Author | Bastos, Otílio Machado Pereira | |
Author | Pratt-Riccio, Lilian Rose | |
Author | Cassiano, Gustavo Capatti | |
Author | Baptista, Andrea Regina Souza | |
Author | Cardoso, Cynthia Chester | |
Author | Banic, Dalma Maria | |
Author | Machado, Ricardo Luiz Dantas | |
Access date | 2022-01-21T14:37:02Z | |
Available date | 2022-01-21T14:37:02Z | |
Document date | 2021 | |
Citation | SALLES, Paula Ferreira et al. CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region. Frontiers in Pharmacology, v. 12, Article 542342, p. 1 - 8, July 2021. | pt_BR |
ISSN | 1663-9812 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50845 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | CYP2D6 | pt_BR |
Subject in Portuguese | Farmacogenética | pt_BR |
Subject in Portuguese | Primaquina | pt_BR |
Subject in Portuguese | Plasmodium vivax | pt_BR |
Subject in Portuguese | Polimorfismo genético | pt_BR |
Subject in Portuguese | Recaídas | pt_BR |
Subject in Portuguese | Amazônia brasileira | pt_BR |
Subject in Portuguese | Áreas endêmicas | pt_BR |
Title | CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fphar.2021.542342 | |
Abstract | Genetic variability was linked with individual responses to treatment and susceptibility to
malaria by Plasmodium vivax. Polymorphisms in the CYP2D6 gene may modulate enzyme
level and activity, thereby affecting individual responses to pharmacological treatment. The
aim of the study was to investigate whether or not CYP2D6 single nucleotide
polymorphisms rs1065852, rs38920-97, rs16947 and rs28371725 are unequally
distributed in malaria by Plasmodium vivax individuals from the Brazilian Amazon
region. The blood samples were collected from 220 unrelated Plasmodium vivax
patients from five different endemic areas. Genotyping was performed using
SNaPshot® and real-time polymerase chain reaction methods. In all five areas, the
rs1065852 (CYP2D6*10, C.100C > T), rs3892097 (CYP2D6*4, 1846C > T) and
rs16947 (CYP2D6*2, C.2850G > A), as a homozygous genotype, showed the lowest
frequencies. The rs28371725 (CYP2D6*41, 2988G > A) homozygous genotype was not
detected, while the allele A was found in a single patient fromMacapá region. No deviations
from Hardy-Weinberg equilibrium were found, although a borderline p-value was observed
(p 0.048) for the SNP rs3892097 in Goianésia do Pará, Pará state. No significant
associations were detected in these frequencies among the five studied areas. For the
SNP rs3892097, a higher frequency was observed for the C/T heterozygous genotype in
the Plácido de Castro and Macapá, Acre and Amapá states, respectively. The distribution
of the CYP2D6 alleles investigated in the different areas of the Brazilian Amazon is not
homogeneous. Further investigations are necessary in order to determine which alleles
might be informative to assure optimal drug dosing recommendations based on
experimental pharmacogenetics. | pt_BR |
Affilliation | Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Faculdade de Medicina de Petrópolis. Petrópolis, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de Lisboa. Instituto de Higiene e Medicina Tropical. Saúde Global e Medicina Tropical. Lisboa, Portugal. | pt_BR |
Affilliation | Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil. | pt_BR |
Subject | Pharmacogenetics | pt_BR |
Subject | CYP2D6 | pt_BR |
Subject | Primaquine | pt_BR |
Subject | Plasmodium vivax | pt_BR |
Subject | Genetic polymorphism | pt_BR |
Subject | Relapses | pt_BR |
Subject | Brazilian Amazon region | pt_BR |
Subject | Endemic Areas | pt_BR |