| Author | Silva, Fátima Conceição | |
| Author | Reis, Clarissa S. M | |
| Author | Luca, Paula Mello de | |
| Author | Silva, Jessica Leite | |
| Author | Santiago, Marta A. | |
| Author | Morrot, Alexandre | |
| Author | Morgado, Fernanda N. | |
| Access date | 2022-01-23T13:07:16Z | |
| Available date | 2022-01-23T13:07:16Z | |
| Document date | 2021 | |
| Citation | SILVA, Fátima Conceição et al. The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection. Cells, v. 10, 1891, p. 1-35, July 2021. | pt_BR |
| ISSN | 2073-4409 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50849 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | Armadilhas extracelulares (ETs) | pt_BR |
| Subject in Portuguese | ETs de neutrófilos | pt_BR |
| Subject in Portuguese | ETs de mastócitos | pt_BR |
| Subject in Portuguese | ETs de eosinófilos | pt_BR |
| Subject in Portuguese | ETs de linfócitos | pt_BR |
| Subject in Portuguese | ETs basófilos | pt_BR |
| Subject in Portuguese | ETs de células dendríticas | pt_BR |
| Subject in Portuguese | ETs de macrófagos | pt_BR |
| Title | The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection | pt_BR |
| Type | Article | |
| DOI | 10.3390/cells10081891 | |
| Abstract | The first formal description of the microbicidal activity of extracellular traps (ETs) containing
DNA occurred in neutrophils in 2004. Since then, ETs have been identified in different
populations of cells involved in both innate and adaptive immune responses. Much of the knowledge
has been obtained from in vitro or ex vivo studies; however, in vivo evaluations in experimental
models and human biological materials have corroborated some of the results obtained. Two types
of ETs have been described—suicidal and vital ETs, with or without the death of the producer cell.
The studies showed that the same cell type may have more than one ETs formation mechanism
and that different cells may have similar ETs formation mechanisms. ETs can act by controlling or
promoting the mechanisms involved in the development and evolution of various infectious and
non-infectious diseases, such as autoimmune, cardiovascular, thrombotic, and neoplastic diseases,
among others. This review discusses the presence of ETs in neutrophils, macrophages, mast cells,
eosinophils, basophils, plasmacytoid dendritic cells, and recent evidence of the presence of ETs in B
lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes. Moreover, due to recently collected
information, the effect of ETs on COVID-19 is also discussed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Programa de Pós-Graduação em Pesquisa Clínica em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós Graduação em Biologia Parasitária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio dee Janeiro. Faculdade de Medicina. Laboratório de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Extracellular traps (ETs) | pt_BR |
| Subject | Neutrophils ETs | pt_BR |
| Subject | Macrophage ETs | pt_BR |
| Subject | Mast cell ETs | pt_BR |
| Subject | Eosinophil ETs | pt_BR |
| Subject | Lymphocyte ETs | pt_BR |
| Subject | Basophil ETs | pt_BR |
| Subject | Dendritic cell ETs | pt_BR |
| Subject | COVID-19 | pt_BR |
