| Author | Silva, Andreon Santos Machado da | |
| Author | Albuquerque, Lawrence Henrique Paz | |
| Author | Ponte, Carlos Germano Garrido de | |
| Author | Almeida, Matheus Rogério de | |
| Author | Faria, Sandra Elizabete Ribeiro de | |
| Author | Ribeiro, Mariana da Silva | |
| Author | Pereira, Evelyn Nunes Goulart da Silva | |
| Author | Antas, Paulo Renato Zuquim | |
| Access date | 2022-01-23T16:47:50Z | |
| Available date | 2022-01-23T16:47:50Z | |
| Document date | 2021 | |
| Citation | SILVA, Andreon Santos Machado da et al . Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains. Human Vaccines & Immunotherapeutics, p. 1-8, Nov. 2021. | pt_BR |
| ISSN | 2164-5515 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50853 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Vacina CG | pt_BR |
| Subject in Portuguese | Citocina | pt_BR |
| Subject in Portuguese | Mycobacterium bovis BCG Moreau | pt_BR |
| Subject in Portuguese | Mycobacterium bovis BCG Rússia | pt_BR |
| Subject in Portuguese | Deformação | pt_BR |
| Title | Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains | pt_BR |
| Type | Article | |
| DOI | 10.1080/21645515.2021.1989913 | |
| Abstract | Tuberculosis (TB) has been a major public health problem worldwide, and the Bacillus Calmette–Guérin
(BCG) vaccine is the only available vaccine against this disease. The BCG vaccine is no longer a single
organism; it consists of diverse strains. The early-shared strains of the BCG vaccine are stronger immunostimulators
than the late-shared strains. In this study, we have employed a simple in vitro human model
to broadly evaluate the differences among four widely used BCG vaccines during the characterization of
strain-specific host immune responses. In general, the BCG Moreau vaccine generated a higher inflammatory
cytokine profile and lower TGF-β levels compared with the Russia, Pasteur, and Danish strains in
the context of early sensitization with TB; however, no changes were observed in the IL-23 levels between
infected and noninfected cultures. Unsurprisingly, the BCG vaccines provided different features, and the
variances among those strains may influence the activation of infected host cells, which ultimately leads
to distinct protective efficacy to tackle TB. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | CG Vaccine | pt_BR |
| Subject | Strains | pt_BR |
| Subject | Cytokine | pt_BR |
| Subject | Mycobacterium bovis BCG Moreau | pt_BR |
| Subject | Mycobacterium bovis BCG Russia | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
