| Author | Ropert, Catherine Maryveite | |
| Author | Franklin, Bernardo Simões | |
| Author | Gazzinelli, Ricardo Tostes | |
| Access date | 2022-01-24T18:46:09Z | |
| Available date | 2022-01-24T18:46:09Z | |
| Document date | 2008 | |
| Citation | ROPERT, Catherine; FRANKLIN, Bernardo Simões; GAZZINELLI, Ricardo Tostes. Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria. Semin Immunopathol, v. 30, n. 1, p. 41-51, 2008. doi: 10.1007/s00281-007-0103-2. | pt_BR |
| ISSN | 1863-2297 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50865 | |
| Sponsorship | COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR | pt_BR |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria | pt_BR |
| Type | Article | |
| DOI | 10.1007/s00281-007-0103-2 | |
| Abstract | Toll-like receptors (TLRs) are important to initiate the innate immune response to a wide variety of pathogens. The protective role of TLRs during infection with protozoan parasites has been established. In this regard, malaria represents an exception where activation of TLRs seems to be deleterious to the host. In this article, we review the recent findings indicating the contrasting role of Myeloid Differentiation Primary-Response gene 88 (MyD88) and TLRs during malaria and infection with other protozoa. These findings suggest that MyD88 may represent an Achilles' heel during Plasmodium infection | pt_BR |
| Affilliation | Laboratory of Immunopathology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Laboratory of Immunopathology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Laboratory of Immunopathology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/ University of Massachusetts. Boston, MA, USA | pt_BR |
| Subject | innate immunity | pt_BR |
| Subject | Toll-like receptors | pt_BR |
| Subject | MyD88 | pt_BR |
| Subject | protozoan parasites | pt_BR |
| Subject | cytokines | pt_BR |
| Subject | dendritic cells | pt_BR |
