| Author | Silveira, Alexandre Barcelos Morais da | |
| Author | Lemos, Elenice Moreira | |
| Author | Adad, Sheila Jorge | |
| Author | Oliveira, Rodrigo Corrêa de | |
| Author | Furness, John B. | |
| Author | Reis, Debora D’Avila | |
| Access date | 2022-01-26T15:35:01Z | |
| Available date | 2022-01-26T15:35:01Z | |
| Document date | 2007 | |
| Citation | SILVEIRA, Alexandre Barcelos Morais da et al. Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells. Hum Pathol., v. 38, n. 8, p. 1256-1264, 2007. doi: 10.1016/j.humpath.2007.01.020. | pt_BR |
| ISSN | 0046-8177 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50905 | |
| Sponsorship | COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR | pt_BR |
| Language | eng | pt_BR |
| Publisher | W B Saunders | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.humpath.2007.01.020 | |
| Abstract | After acute infestation with the Chagas disease parasite, Trypanosoma cruzi, some patients who are serologically positive develop chronic megacolon and megaesophagus, whereas others are symptom-free. Chagas disease with gastrointestinal involvement involves an inflammatory invasion of the enteric plexuses and degeneration of enteric neurons. It is known that glial cells can be involved in enteric inflammatory responses. The aims were to determine the nature of any difference in lymphocytic invasion, enteric neurons, and enteric glial cells in seropositive individuals with and without megacolon. We have compared colonic tissue from serologically positive individuals with and without symptoms and from seronegative controls. Subjects with megacolon had significantly more CD-57 natural killer cells and TIA-1 cytotoxic lymphocytes within enteric ganglia, but numbers of CD-3 and CD-20 immunoreactive cells were not significantly elevated. The innervation of the muscle was substantially reduced to about 20% in megacolon, but asymptomatic seropositive subjects were not different to seronegative controls. Glial cell loss occurred equally in symptomatic and unaffected seropositive subjects, although the proportion with glial fibrillary acidic protein was greater in seropositive, nonsymptomatic subjects. Development of megacolon after acute infection with T cruzi is associated with maintained invasion of enteric ganglia with cytotoxic T cells and loss of muscle innervation, but changes in glial cell numbers are not associated with progression of enteric neuropathy. | pt_BR |
| Affilliation | Department of Morphology. Instituto de Ciencias Biologicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Department of Pathology. U Universidade Federal do Espirito Santo, Vitoria, ES, Brazil | pt_BR |
| Affilliation | Department of Pathology. Medical School of Triangulo Mineiro. Uberaba, MG, Brazil | pt_BR |
| Affilliation | Research Center Rene Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Department of Anatomy and Cell Biology and Center for Neuroscience. University of Melbourne. Victoria, Australia | pt_BR |
| Affilliation | Department of Morphology. Instituto de Ciencias Biologicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | chagasic megacolon | pt_BR |
| Subject | inflammatory cells | pt_BR |
| Subject | enteric nervous system | pt_BR |
| Subject | glial cells | pt_BR |
| Subject | enteric nerves | pt_BR |
