| Author | Sousa, Luciana Pereira de | |
| Author | Gomes, Flávia Lima Ribeiro | |
| Author | Almeida, Roberto Farina de | |
| Author | Souza, Tadeu Mello e | |
| Author | Werneck, Guilherme Loureiro | |
| Author | Souza, Diogo Onofre | |
| Author | Ribeiro, Cláudio Tadeu Daniel | |
| Access date | 2022-01-29T17:53:49Z | |
| Available date | 2022-01-29T17:53:49Z | |
| Document date | 2021 | |
| Citation | SOUSA, Luciana Pereira de et al. Immune system challenge improves recognition memory and reverses malaria‑induced cognitive impairment in mice. Scientific Reports, v. 11, 14857, p. 1 - 11, 2021. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50944 | |
| Language | eng | pt_BR |
| Publisher | Nature | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Desafio do sistema imunológico | pt_BR |
| Subject in Portuguese | Melhoria | pt_BR |
| Subject in Portuguese | Memória de reconhecimento | pt_BR |
| Subject in Portuguese | Reverte a malária | pt_BR |
| Subject in Portuguese | Induzida comprometimento cognitivo | pt_BR |
| Subject in Portuguese | Camundongos | pt_BR |
| Title | Immune system challenge improves recognition memory and reverses malaria‑induced cognitive impairment in mice | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41598-021-94167-8 | |
| Abstract | The immune system plays a role in the maintenance of healthy neurocognitive function. Different
patterns of immune response triggered by distinct stimuli may affect nervous functions through
regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here,
we investigate the effect of immune stimulation on cognitive-behavioural parameters in healthy mice
and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that
immune modulation induced by a specific combination of immune stimuli that induce a type 2 immune
response can enhance long-term recognition memory in healthy adult mice subjected to novel object
recognition task (NORT) and reverse a lack of recognition ability in NORT and anxiety-like behaviour
in a light/dark task that result from a single episode of mild Plasmodium berghei ANKA malaria. Our
findings suggest a potential use of immunogens for boosting and recovering recognition memory that
may be impaired by chronic and infectious diseases and by the effects of ageing. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Departamento de Bioquímica. Porto Alegre, RS, Brasil / Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Programa de Pós‑Graduação em Ciências Biológicas. Ouro Preto, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Estudos de Saúde Coletiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Epidemiologia do Instituto de Medicina Social. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Estudos de Saúde Coletiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Immune system challenge | pt_BR |
| Subject | Recognition memory | pt_BR |
| Subject | Reverses malaria | pt_BR |
| Subject | Induced cognitive impairment | pt_BR |
| Subject | Mice | pt_BR |
