| Author | Lima, Luciana Alves Rodrigues dos Santos | |
| Author | Alves, Tânia Maria de Almeida | |
| Author | Zani, Carlos Leomar | |
| Author | Sales Junior, Policarpo Ademar | |
| Author | Romanha, Alvaro José | |
| Author | Johann, Susana | |
| Author | Cisalpino, Patrícia Silva | |
| Author | Pimenta, Lúcia Pinheiro Santos | |
| Author | Boaventura, Maria Amelia Diamantino | |
| Access date | 2022-02-01T15:05:49Z | |
| Available date | 2022-02-01T15:05:49Z | |
| Document date | 2014 | |
| Citation | LIMA, Luciana Alves Rodrigues dos et al. In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae). An Acad Bras Cienc., vol. 86, n. 2, p, 829-839, 2014 | pt_BR |
| ISSN | 0001-3765 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50974 | |
| Language | eng | pt_BR |
| Publisher | Academia Brasileira de Ciências | pt_BR |
| Rights | open access | pt_BR |
| Title | In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae) | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0001-3765201420130048 | |
| Abstract | Annona cornifolia A. St. -Hil. is a small annual perennial tree found in the Brazilian savannah; their green fruit is popularly used in the treatment of ulcers. The acetogenins isolated from the seeds of Annona cornifolia previously showed to possess antioxidant activity. In continuation of our investigations on the biological activities of acetogenins, four binary mixtures and ten pure adjacent bis-tetrahydrofuran annonaceous acetogenins were evaluated: the cytotoxic (against three human tumor cell lines), antifungal (against Paracoccidioides brasiliensis), trypanocidal (against Trypanosoma cruzi) and leishmanicidal (against Leishmania amazonensis) activities. Acetogenins presented cytotoxic activity confirming their potential use in anti-cancer therapy. Regarding leishmanicidal and trypanocidal activities, an inhibition of 87% of L. amazonensis amastigotes and 100% of T. cruzi amastigotes and trypomastigotes was observed, when tested at the concentration of 20 mu g mL(-1). Moreover, six acetogenins showed more activity against all the three tested isolates of P. brasiliensis than trimethoprim-sulfamethoxazole, a drug used for treating paracoccidioidomycosis. Thus, acetogenins may be an alternative in treating a number of diseases that have a huge impact on millions of people worldwide. This paper reports for the first time the antifungal, leishmanicidal and trypanocidal activities for these acetogenins | pt_BR |
| Affilliation | Universidade Federal de São João Del Rei. Divinópolis, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais.Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | Annona cornifolia | pt_BR |
| Subject | Annona cornifolia | pt_BR |
| Subject | Annona cornifolia | pt_BR |
| Subject | cytotoxic | pt_BR |
| Subject | antifungal | pt_BR |
| Subject | leishmanicidal | pt_BR |
