| Author | Araujo, Fernanda Fortes de | |
| Author | Gomes, Juliana Assis Silva | |
| Author | Rocha, Manoel Otavio Costa da | |
| Author | Williams-Blangero, Sarah | |
| Author | Pinheiro, Vladimir Martins | |
| Author | Morato, Maria Jose Ferreira | |
| Author | Oliveira, Rodrigo Correa de | |
| Access date | 2022-02-01T16:27:57Z | |
| Available date | 2022-02-01T16:27:57Z | |
| Document date | 2007 | |
| Citation | ARAUJO, Fernanda Fortes et al. Potential role of CD4+CD25HIGH regulatory T cells in morbidity in Chagas disease. Frontiers in Bioscience, v. 12, p. 2797-2806, 2007 | pt_BR |
| ISSN | 1093-9946 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50975 | |
| Sponsorship | CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO | pt_BR |
| Language | eng | pt_BR |
| Publisher | Frontiers In Bioscience Publications | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Potential role of CD4(+)CD25(HIGH) regulatory T cells in morbidity in Chagas disease | pt_BR |
| Type | Article | |
| DOI | 10.2741/2273 | |
| Abstract | Several immunoregulatory mechanisms are proposed to be effective both in human and experimental Trypanosoma cruzi infection. However, the role of CD4(+)CD25(high) T cells in Chagas disease has not yet been elucidated. These cells are critical for the regulation of immune response to infectious agents and in the control of autoimmune diseases. In this study, the presence of CD4(+)CD25(high) regulatory T cells in the whole blood of non-infected individuals ( NI), and patients with the indeterminate (IND) and cardiac form ( CARD) of Chagas disease was evaluated. To further characterize this population of regulatory cells, the co-expression of CTLA-4, CD62L, CD45RO, CD45RA, HLA-DR, CD40L, CD69, CD54, IL-10R and the intracellular molecules FOXP3 and IL-10 on the CD4(+)CD25(high) T lymphocytes was examined. FOXP3 was expressed by the majority of CD4(+)CD25(high) when compared with the other CD4(+) T cells subsets in patients with Chagas disease. Patients with the IND form of the disease had a higher frequency of circulating regulatory CD4(+)CD25(high) T cells than patients with the CARD form. Moreover, there was an increase in CD4(+)CD25(high)FOXP3(+) cells that were also IL-10(+) in the IND group whereas, in the CARD group, there was an increase in the percentage of CD4(+)CD25(high)FOXP3(+) cells that expressed CTLA-4. These data suggest that IL-10 produced by regulatory T cells is effective in controlling disease development in patients with the IND form. However, in individuals with the CARD form of the disease, the same regulatory mechanism, mediated by IL-10 and CTLA-4 expression is not sufficient to control the progression of the disease. The data suggest that CD4(+)CD25(high)FOXP3(+) regulatory T cells in patients with Chagas disease might play a role in the immune response against T. cruzi infection although with distinct effects in patients with the IND and CARD forms of disease | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pos-Graduacao em Ciencias da Saude: Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Southwest Foundation for Biomedical Research Department of Genetic. San Antonio, Texas | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pos-Graduacao em Ciencias da Saude: Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil/Faculdade Sao Camilo. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
