| Author | Lopes, Amanda de O. | |
| Author | Lima, Lyana R. P. | |
| Author | Tozetto-Mendoza, Tania R. | |
| Author | Martinelli, Katrini G. | |
| Author | Morgado, Mariza G. | |
| Author | Pilotto, José H. | |
| Author | Paula, Vanessa Salete S. de | |
| Access date | 2022-02-01T18:56:19Z | |
| Available date | 2022-02-01T18:56:19Z | |
| Document date | 2021 | |
| Citation | LOPES, Amanda de O. et al. Low prevalence of human gammaherpesvirus 8 (HHV-8) infection among HIV-infected pregnant women in Rio de Janeiro, Brazil. The Journal of Maternal-Fetal & Neonatal Medicine, v. 34, n. 20, p. 3458-3461, Oct. 2019. | pt_BR |
| ISSN | 1476-7058 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50977 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Coinfecção | pt_BR |
| Subject in Portuguese | Herpes vírus gama humano 8 | pt_BR |
| Subject in Portuguese | Vírus da imunodeficiência humana | pt_BR |
| Subject in Portuguese | Mulheres grávidas | pt_BR |
| Subject in Portuguese | Prevalência | pt_BR |
| Subject in Portuguese | Rio de Janeiro | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Low prevalence of human gammaherpesvirus 8 (HHV-8) infection among HIV-infected pregnant women in Rio de Janeiro, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1080/14767058.2019.1685967 | |
| Abstract | Pregnant women coinfected with the human immunodeficiency virus (HIV) and human gammaherpesvirus
8 (HHV-8) are at higher risk of Kaposi’s sarcoma development, increased viral load,
and vertical transmission of these viruses. A total of 131 pregnant women infected with HIV
were examined for antibodies against HHV-8 latency-associated nuclear antigen (LANA) and lytic
antigens using immunofluorescence assays. The presence of HHV-8 DNA was confirmed using
real-time polymerase chain reaction (qPCR) and nested PCR. Overall, 0.8% (1/131) of the patients
contained antibodies to HHV-8 LANA and lytic antigens, and no HHV-8 DNA was detected. This
study, including a small population of HIV-infected pregnant women in Brazil, indicates a low
prevalence of HHV-8 seropositivity and absence of active infection in this group. However, a
potential role of HHV-8 in the increased transmission and pathogenic activity of HIV in pregnant
women is suggested. Attention should be given to the emergence of HHV-8 infection in this
population group in order to avoid comorbidities and transmission of HIV. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laborat orio de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laborat orio de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia, LIM52. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Espírito Santo. Departamento de Medicina Social. Vitória, ES, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil . | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu, Nova Iguaçu, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil . | pt_BR |
| Subject | Coinfection | pt_BR |
| Subject | Human gamma herpesvirus 8 | pt_BR |
| Subject | Human immunodeficiency virus | pt_BR |
| Subject | Pregnant women | pt_BR |
| Subject | Prevalence | pt_BR |
| Subject | Rio de Janeiro | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1476-4954 | |
| Embargo date | 2023 | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
