| Author | Castro, Lisie Souza | |
| Author | Rezende, Grazielli Rocha de | |
| Author | Fernandes, Fernanda Rodas Pires | |
| Author | Bandeira, Larissa Melo | |
| Author | Cesar, Gabriela Alves | |
| Author | Lago, Barbara Vieira do | |
| Author | Gouvêa, Michele Soares Gomes | |
| Author | Motta-Castro, Ana R. C. | |
| Access date | 2022-02-05T20:37:00Z | |
| Available date | 2022-02-05T20:37:00Z | |
| Document date | 2021 | |
| Citation | CASTRO, Lisie Souza et al. HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks. Plos One, v. 16, n. 9, e0256818, p. 1 - 10, Sept. 2021. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51036 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Infecção HAV | pt_BR |
| Subject in Portuguese | Importância para evitar surtos | pt_BR |
| Subject in Portuguese | Vigilância | pt_BR |
| Subject in Portuguese | Homens que fazem sexo com homens | pt_BR |
| Subject in Portuguese | Anticorpos Anti-Hepatite A | pt_BR |
| Title | HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0256818 | |
| Abstract | Background
Hepatitis A is a fecal-oral infection caused by hepatitis A virus (HAV). Men who have sex
with men (MSM) and transgender women (TW) have been reported as target groups for
HAV infection. This study aimed to determine the seroprevalence, risk factors, and circulating
strains associated with HAV infection among MSM and TW in Central Brazil.
Methods
A cross-sectional study was conducted from November 2011 to September 2013. Serum
samples were collected from 425 individuals for anti-HAV antibody testing and HAV molecular
characterization. Of them, 149 (35.1%) participants were self-identified as transgender
women. Statistical analysis was performed to evaluate the risk factors of HAV seropositivity.
Results
The seroprevalence of HAV exposure was 69.7% (95% Confidence Interval: 65.3–74.0%).
Serological evidence of HAV was significantly higher in participants who self-identified as
transgender women (83.2%) than MSM (62.3%). Increasing age, non-white race, and lower
monthly household income were independently associated with HAV exposure among
MSM. Only lower monthly household income was independently associated with HAV exposure
among TW. One anti-HAV IgM positive sample, from a transgender woman (0.2%),
was detected and classified as subgenotype IA. Conclusions
High HAV prevalence was observed, markedly among TW. Considering the risky
sexual behaviors this population is exposed to, HAV vaccination and prevention programs targeting this population should be considered to prevent outbreaks and the burden of the
disease. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil / Universidade Federal de Mato Grosso. Rondonópolis, MT Brasil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil / Ministério da Agricultura, Pecuária e Abastecimento. Laboratório Nacioanl Agropecuário. MInas Gerais, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Rio de Janeiro, Mato Grosso do Sul, Brasil. | pt_BR |
| Subject | HAV infection | pt_BR |
| Subject | Men who have sex with men | pt_BR |
| Subject | Surveillance | pt_BR |
| Subject | Import to avoid outbreaks | pt_BR |
| Subject | Hepatitis A Virus Antibodies | pt_BR |
| DeCS | Hepatitis A Virus Antibodies | pt_BR |
| DeCS | Anticorpos Anti-Hepatite A | pt_BR |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
