| Author | Dutra, Filipe S. Pereira | |
| Author | Bozza, Patrícia T. | |
| Access date | 2022-02-06T17:49:56Z | |
| Available date | 2022-02-06T17:49:56Z | |
| Document date | 2021 | |
| Citation | DUTRA, Filipe S. Pereira; BOZZA, Patrícia T. Lipid droplets diversity and functions in inflammation and immune response. Expert Review of Proteomics, v. 18, n. 9, p. 809-825, Oct. 2021. | pt_BR |
| ISSN | 1744-8377 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51041 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Imunometabolismo | pt_BR |
| Subject in Portuguese | Metabolismo lipídico | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Gotículas de lipídios | pt_BR |
| Subject in Portuguese | Proteoma de organela | pt_BR |
| Subject in Portuguese | Eicosanóides | pt_BR |
| Subject in Portuguese | Interação de organelas | pt_BR |
| Title | Lipid droplets diversity and functions in inflammation and immune response | pt_BR |
| Type | Article | |
| DOI | 10.1080/14789450.2021.1995356 | |
| Abstract | Introduction: Lipid droplets (LDs) are dynamic and evolutionary conserved lipid-enriched organelles
composed of a core of neutral lipids surrounded by a monolayer of phospholipids associated with
a diverse array of proteins that are cell- and stimulus-regulated. Far beyond being simply a deposit of
neutral lipids, accumulating evidence demonstrate that LDs act as spatial and temporal local for lipid
and protein compartmentalization and signaling organization.
Areas covered: This review focuses on the progress in our understanding of LD protein diversity and
LD functions in the context of cell signaling and immune responses, highlighting the relationship
between LD composition with the multiple roles of this organelle in immunometabolism, inflammation
and host-response to infection.
Expert opinion: LDs are essential platforms for various cellular processes, including metabolic regulation,
cell signaling, and immune responses. The functions of LD in infection and inflammatory disease
are associated with the dynamic and complexity of their proteome. Our contemporary view place LDs
as critical regulators of different inflammatory and infectious diseases and key markers of leukocyte
activation. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Lipid metabolism | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Lipid droplets | pt_BR |
| Subject | Organelle proteome | pt_BR |
| Subject | Eicosanoids | pt_BR |
| Subject | Organelle interaction | pt_BR |
| Subject | Immunometabolism | pt_BR |
| Embargo date | 2024 | |
