| Author | Mello, Vinicius M. | |
| Author | Bianchi, Lucas M. | |
| Author | Sousa, Paulo Sergio F. | |
| Author | Tavares, Pedro S. | |
| Author | Di Salvo, Daniel R. G. | |
| Author | Ginuino, Cleber F. | |
| Author | Almeida, Nathalia A. A. | |
| Author | Fernandes, Carlos A. S. | |
| Author | Mello, Francisco C. A. | |
| Author | Villar, Livia M. | |
| Author | Lewis-Ximenez, Lia L. | |
| Author | Lago, Barbara V. | |
| Access date | 2022-02-07T14:56:35Z | |
| Available date | 2022-02-07T14:56:35Z | |
| Document date | 2022 | |
| Citation | MELLO, Vinicius M. et al. Increase in Hepatitis A Cases Linked to Imported Strains to Rio de Janeiro, Brazil: A Cross-Sectional Study. Viruses, v. 14, n. 303, p. 1 -19, Feb. 2022. | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51051 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vírus da Hepatite A | pt_BR |
| Subject in Portuguese | Hepatite A no Brasil | pt_BR |
| Subject in Portuguese | Epidemiologia molecular | pt_BR |
| Subject in Portuguese | Cepas de surto | pt_BR |
| Subject in Portuguese | Cepas endêmicas | pt_BR |
| Subject in Portuguese | Transmissão sexual | pt_BR |
| Subject in Portuguese | Rio de Janeiro | pt_BR |
| Title | Increase in Hepatitis A Cases Linked to Imported Strains to Rio de Janeiro, Brazil: A Cross-Sectional Study | pt_BR |
| Type | Article | |
| DOI | 10.3390/v14020303 | |
| Abstract | This study aims to evaluate the epidemiological and molecular features associated with
HAV transmission in adults in Rio de Janeiro during a period of increased registered cases of HAV
(2017–2018). Socio-epidemiological data and serum samples from anti-HAV IgM+ individuals were
obtained. HAV RNA was RT-PCR amplified and sequenced for further phylogenetic and phylogeographic
analyses. From fifty-two HAV IgM+ individuals, most were men (78.85%; p = 0.024), aged
20–30 years old (84.61%; p < 0.001), resided in the Rio de Janeiro north zone (31/52; 59.62%; p = 0.001),
and are men who have sex with men (MSM) (57.69%; p = 0.002). Sexual practices were more frequent
(96%) than others risk factors (food-borne (44%), water-borne (42.31%), and parenteral (34.62%)).
Individuals who traveled to endemic regions had a 7.19-fold (1.93–36.04; p < 0.01) increased risk of
HAV. Phylogenetic analysis revealed four distinct clades of subgenotype IA, three of them comprised
sequences from European/Asian MSM outbreaks and one from Brazilian endemic strains.
Bayesian Inference showed that the imported strains were introduced to Brazil during large mass
sportive events. Sexual orientation and sexual practices may play a role in acquiring HAV infection.
Public policies targeting key populations must be implemented to prevent further dissemination of
HAV and other STIs. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Dederal do Rio de Janeiro. Instituto de Geociências. Grupo de Pesquisa em Território e Política. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Dederal do Rio de Janeiro. Instituto de Geociências. Laboratório de Cartografia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Secretaria Estadual de Saúde do Rio de Janeiro. Divisão de Hepatites. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos - Bio -Manguinhos. Rio de Janeiro, RJ, Brasil. . | pt_BR |
| Subject | Hepatitis A virus | pt_BR |
| Subject | Hepatitis A in Brazil | pt_BR |
| Subject | Molecular epidemiology | pt_BR |
| Subject | Outbreak strains | pt_BR |
| Subject | Endemics strains | pt_BR |
| Subject | Sexual transmission | pt_BR |
