| Author | Silva, Kyssia Karen de Paiva e | |
| Author | Oliveira, Erick Esteves de | |
| Author | Elias, Carolina Martins Moreira | |
| Author | Pereira, Ingrid Estevam | |
| Author | Pinheiro, Roberta Olmo | |
| Author | Sarno, Euzenir Nunes | |
| Author | Duthie, Malcolm Scott | |
| Author | Teixeira, Henrique Couto | |
| Access date | 2022-02-08T17:48:45Z | |
| Available date | 2022-02-08T17:48:45Z | |
| Document date | 2021 | |
| Citation | SILVA, Kyssia Karen de Paiva e et al. Serum IgA Antibodies Specific to M. leprae Antigens as Biomarkers for Leprosy Detection and Household Contact Tracking. Frontiers in Medicine, v. 8, Article 698495, p. 1 - 7, Aug. 2021. | pt_BR |
| ISSN | 2298-858X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51085 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Hanseníase | pt_BR |
| Subject in Portuguese | Diagnóstico | pt_BR |
| Subject in Portuguese | Bioomarcador | pt_BR |
| Subject in Portuguese | IgA | pt_BR |
| Subject in Portuguese | NDO-HSA | pt_BR |
| Subject in Portuguese | LID-1 | pt_BR |
| Subject in Portuguese | Características operacionais do receptor | pt_BR |
| Subject in Portuguese | Contato doméstico | pt_BR |
| Title | Serum IgA Antibodies Specific to M. leprae Antigens as Biomarkers for Leprosy Detection and Household Contact Tracking | pt_BR |
| Type | Article | |
| DOI | 10.3389/fmed.2021.698495 | |
| Abstract | Leprosy remains endemic in several developing countries, such as India and Brazil,
in part due to delayed diagnosis that facilitates ongoing transmission. Although
immunoglobulins against severalMycobacteriumleprae antigens have been indicated for
the early diagnosis, and IgA participates in the early stages of leprosy and in subclinical
infection, relatively little research has examined anti-M. leprae IgA responses. Here, we
investigated serumIgA reactivity against NDO-HSA, LID-1 and NDO-LID, in paucibacillary
(PB) and multibacillary (MB) patients and their household contacts, using enzyme-linked
immunosorbent assay (ELISA). Diagnostic accuracy of each ELISA was evaluated by
receiver operating characteristic (ROC) curve analysis. Our data reveal elevated IgA
serum levels against the three M. leprae specific antigens in MB patients, whereas
IgA reactivity in PB patients was increased only to NDO-HSA. Further, MB and PB
household contacts displayed higher IgA reactivity to NDO-HSA than non-endemic
controls. Our data suggestmeasurement of serumIgA against NDO-HSA as an additional
tool in the diagnosis and classification of the disease, with potential utility for household
contact follow-up. | pt_BR |
| Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | HDT Biocorp. Seattle, WA, USA. | pt_BR |
| Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brasil. | pt_BR |
| Subject | Leprosy | pt_BR |
| Subject | Diagnosis | pt_BR |
| Subject | IgA | pt_BR |
| Subject | NDO-HSA | pt_BR |
| Subject | LID-1 | pt_BR |
| Subject | ROC analysis | pt_BR |
| Subject | Household contact | pt_BR |
| Subject | Biomarker | pt_BR |
