| Author | Morgado, Sergio | |
| Author | Ramos, Nilcéia de Veiga | |
| Author | Freitas, Fernanda | |
| Author | Fonseca, Érica Lourenço da | |
| Author | Vicente, Ana Carolina | |
| Access date | 2022-02-08T18:54:24Z | |
| Available date | 2022-02-08T18:54:24Z | |
| Document date | 2021 | |
| Citation | MORGADO, Sergio et al. Mycolicibacterium fortuitum genomic epidemiology, resistome and virulome. Memórias do instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210247, p. 1 - 5, Oct. 2021. | pt_BR |
| ISSN | 0074-0206 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51096 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Rifampicina | pt_BR |
| Subject in Portuguese | Resistência | pt_BR |
| Subject in Portuguese | Sistema de secreção tipo VII | pt_BR |
| Subject in Portuguese | Patógeno oportunista | pt_BR |
| Title | Mycolicibacterium fortuitum genomic epidemiology, resistome and virulome | pt_BR |
| Type | Article | |
| Abstract | BACKGROUND Mycolicibacterium fortuitum is an opportunistic pathogen associated with human and animal infection worldwide.
Studies concerning this species are mainly represented by case reports, some of them addressing drug susceptibility with a focus
on a specific geographic region, so there is a gap in relation to the global epidemiological scenario.
OBJECTIVES We aimed determine the global epidemiological scenario of M. fortuitum and analyse its traits associated with
pathogenicity.
METHODS Based on publicly available genomes of M. fortuitum and a genome from Brazil (this study), we performed a genomic
epidemiology analysis and in silico and in vitro characterisation of the resistome and virulome of this species.
FINDINGS Three main clusters were defined, one including isolates from the environment, human and animal infections
recovered over nearly a century. An apparent intrinsic resistome comprises mechanisms associated with macrolides, betalactams,
aminoglycosides and antitubercular drugs such as rifampin. Besides, the virulome presented Type VII secretion systems
(T7SS), including ESX-1, ESX-3, ESX-4 and ESX-4-bis, some of which play a role on the virulence of Mycobacteriaceae species.
MAIN CONCLUSIONS Here, M. fortuitum was revealed as a reservoir of an expressive intrinsic resistome, as well as a virulome
that may contribute to its success as a global opportunist pathogen. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de Vassouras. Faculdade de Ciências Médicas de Maricá. Maricá, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Arr | pt_BR |
| Subject | Rifampin | pt_BR |
| Subject | Resistance | pt_BR |
| Subject | ESX | pt_BR |
| Subject | Type VII secretion system | pt_BR |
| Subject | Opportunist pathogen | pt_BR |
| e-ISSN | 1678-8060 | |
