| Author | Rossi, Átila Duque | |
| Author | Faucz, Fabio Rueda | |
| Author | Melo, Adriana | |
| Author | Azevedo, Girlene Souza de | |
| Author | Pezzuto, Paula | |
| Author | Bezerra, Ohanna Cavalcanti de Lima | |
| Author | Manta, Fernanda Saloum de Neves | |
| Author | Azamor, Tamiris | |
| Author | Reis, Bruno Luiz Fonseca Schamber | |
| Author | Tanuri, Amilcar | |
| Author | Moraes, Milton Ozório | |
| Author | Aguiar, Renato Santana de | |
| Author | Stratakis, Constantine A. | |
| Author | Cardoso, Cynthia Chester | |
| Access date | 2022-02-09T19:00:57Z | |
| Available date | 2022-02-09T19:00:57Z | |
| Document date | 2021 | |
| Citation | ROSSI, Átila Duque et al. Association between maternal non-coding interferon-λ polymorphisms and congenital Zika syndrome in a cohort from brazilian northeast. Viruses, v. 13, n. 11, p. 1-6, 10 Nov. 2021. | |
| ISSN | 1999-4915 | |
| URI | https://www.arca.fiocruz.br/handle/icict/51122 | |
| Description | Produção científica do Laboratório de Hanseníase. | pt_BR |
| Language | eng | en_US |
| Publisher | MDPI | |
| Rights | open access | |
| Title | Association between maternal non-coding interferon-λ polymorphisms and congenital Zika syndrome in a cohort from brazilian northeast | en_US |
| Type | Article | |
| DOI | 10.3390/v13112253 | |
| Abstract | Congenital Zika syndrome (CZS) is characterized by a diverse group of congenital malformations induced by ZIKV infection during pregnancy. Type III interferons have been associated with placental immunity against ZIKV and restriction of vertical transmission in mice, and non-coding single-nucleotide polymorphisms (SNPs) on these genes are well known to influence susceptibility to other viral infections. However, their effect on ZIKV pathogenesis has not yet been explored. To investigate whether maternal non-coding SNPs at IFNL genes are associated with CZS, 52 women infected with ZIKV during pregnancy were enrolled in a case–control association study. A total of 28 women were classified as cases and 24 as controls based on the presence or absence of CZS in their infants, and seven Interferon-λ non-coding SNPs (rs12980275, rs8099917, rs4803217, rs4803219, rs8119886, rs368234815, rs12979860) were genotyped. The results of logistic regression analyses show an association between the G allele at rs8099917 and increased susceptibility to CZS under a log-additive model (adjustedOR = 2.80; 95%CI = 1.14–6.91; p = 0.02), after adjustment for trimester of infection and genetic ancestry. These results provide evidence of an association between Interferon-λ SNPs and CZS, suggesting rs8099917 as a promising candidate for further studies on larger cohorts. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Section on Endocrinology and Genetics. Bethesda, MD, USA. | |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil. | |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Centro Universitário UniFacisa. Faculdade de Ciências Médicas de Campina Grande. Núcleo de Genética Médica. Campina Grande, PB, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Biologia Integrativa. Belo Horizonte, MG, Brasil. | |
| Affilliation | National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Section on Endocrinology and Genetics. Bethesda, MD, USA. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | |
| Subject | Zika | en_US |
| Subject | Type III interferon | en_US |
| Subject | Polymorphism | en_US |
| Subject | Congenital Zika syndrome | en_US |
| Subject | Genetic susceptibility | en_US |
| e-ISSN | 1999-4915 | |
