| Author | Alcântara, Lorena Kimberly Silva | |
| Author | Machado, Luiz Felipe Carreiro | |
| Author | Ceravolo, Isabela Penna | |
| Author | Santos, Renan Martins dos | |
| Author | Souza, Marcus Vinícius Dias | |
| Access date | 2022-02-10T13:09:57Z | |
| Available date | 2022-02-10T13:09:57Z | |
| Document date | 2021 | |
| Citation | ALCÂNTARA, Lorena Kimberly Silva et al. Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli. Biointerface Research in Applied Chemistry, v. 11, n. 1, p. 8210 – 8217, 2021. doi.org/10.33263/BRIAC111.82108217 | pt_BR |
| ISSN | 2069-5837 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51131 | |
| Language | eng | pt_BR |
| Publisher | Resurchify | pt_BR |
| Rights | open access | pt_BR |
| Title | Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli | pt_BR |
| Type | Article | pt_BR |
| Abstract | Escherichia coli is naturally present at the gastrointestinal tract of humans, but is also involved in diseases such as urinary tract infection. The current scenario of bacterial resistance to antimicrobials raises the demand for new drugs, and natural products represent interesting sources of bioactive compounds. Here we investigated the cytotoxicity and antimicrobial potential of 80% methanolic extracts of Spondias tuberosa (umbu), Spondias purpurea (seriguela), and Theobroma grandiflorum (cupuaçu) fruit juice pulps against clinical isolates of uropathogenic E. coli. Phytochemical aspects of the pulps were elucidated, and their antioxidant properties were analyzed. The minimal inhibitory concentration (MIC) of the extracts was of 500 µg/mL, and no toxicity was observed against BGM cells. Vitamin C and total carbohydrates were not in accordance to the levels
determined in the legislation. We used HPLC to confirm the presence of flavonoids. To the best of our
knowledge, this is the first report of the antimicrobial potential of these fruit pulps. Our data open doors for more studies with chromatographic fractions and isolated flavonoids from these pulps. | pt_BR |
| Affilliation | PharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil | pt_BR |
| Affilliation | PharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil | pt_BR |
| Affilliation | René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | PharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil/Integrated Pharmacology and Drug Interactions Research Group. Brazil | pt_BR |
| Affilliation | PharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil/Integrated Pharmacology and Drug Interactions Research Group. Brazil | pt_BR |
| Subject | plant extract | pt_BR |
| Subject | uropathogenic E. coli | pt_BR |
| Subject | antimicrobial | pt_BR |
| Subject | umbu | pt_BR |
| Subject | seriguela | pt_BR |
| Subject | cupuaçu | pt_BR |
