| Author | Paixão, Enny Santos da | |
| Author | Blencowe, Hannah | |
| Author | Falcao, Ila Rocha | |
| Author | Ohuma, Eric O. | |
| Author | Rocha, Aline dos Santos | |
| Author | Alves, Flávia Jôse Oliveira | |
| Author | Costa, Maria da Conceição Nascimento | |
| Author | Idueta, Lorena Suárez | |
| Author | Ortelan, Naiá | |
| Author | Smeeth, Liam | |
| Author | Rodrigues, Laura C. | |
| Author | Lawn, Joy E | |
| Author | Almeida, Marcia Furquim de | |
| Author | Ichihara, Maria Yury | |
| Author | Silva, Rita de Cássia Ribeiro | |
| Author | Teixeira, Maria Gloria | |
| Author | Barreto, Mauricio Lima | |
| Access date | 2022-02-10T17:36:46Z | |
| Available date | 2022-02-10T17:36:46Z | |
| Document date | 2021 | |
| Citation | Paixão, Enny S.et al. Risk of mortality for small newborns in Brazil, 2011-2018: A national birth cohort study of 17.6 million records from routine register-based linked data. The Lancet, v. 3, p. 1-8, 2021. | pt_BR |
| ISSN | 0140-6736 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51138 | |
| Description | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre. London School of Hygiene & Tropical Medicine. London, WC1E 7HT, UK. Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre. London School of Hygiene & Tropical Medicine. London WC1E 7HT, UK. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil. Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre. London School of Hygiene & Tropical Medicine. London WC1E 7HT, UK Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia Federal. Instituto de Saúde Coletiva. Salvador, BA, Brasil Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia Federal. Instituto de Saúde Coletiva. Salvador, BA, Brasil. Mexican Society of Public Health. Miguel Hidalgo, Ciudad de México, México. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre. London School of Hygiene & Tropical Medicine. London WC1E 7HT, UK. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre. London School of Hygiene & Tropical Medicine. London WC1E 7HT, UK. Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre. London School of Hygiene & Tropical Medicine. London WC1E 7HT, UK. Universidade de São Paulo. Faculdade de Saúde Pública, São Paulo, SP, Brasil. Universidade de São Paulo. Faculdade de Saúde Pública, São Paulo, SP, Brasil. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia Federal. Instituto de Saúde Coletiva. Salvador, BA, Brasil. Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre. London School of Hygiene & Tropical Medicine. London WC1E 7HT, UK / Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil. | pt_BR |
| Sponsorship | Wellcome Trust. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Nascimento prematuro | pt_BR |
| Subject in Portuguese | Mortalidade infantil | pt_BR |
| Subject in Portuguese | Fenótipo | pt_BR |
| Subject in Portuguese | Neonatal | pt_BR |
| Title | Risk of mortality for small newborns in Brazil, 2011-2018: A national birth cohort study of 17.6 million records from routine register-based linked data | pt_BR |
| Type | Article | pt_BR |
| DOI | doi.org/10.1016/j.lana.2021.100045 | |
| Abstract | Background: Preterm birth ( < 37 weeks), low birth weight (LBW, < 2500g), and small for gestational age (SGA, < 10th centile of birth weight for gestational age and sex) are markers of newborn vulnerability with a high risk of mortality. We estimated the prevalence of phenotypes combining these three markers and quantified the mortality risk associated with them. Methods: Population-based cohort study using routine register-based linked data on all births and deaths in Brazil from January 1, 2011, to December 31, 2018. We estimated the prevalence of preterm, LBW, and SGA individually and for phenotypes combining these characteristics. The mortality risk associated with each phenotype: early neonatal, late neonatal, neonatal, post-neonatal, infant, 1-4 years, and under five years was quantified using mortality rates and hazard ratios (HRs) with 95% confidence interval (CI) were estimated using Cox proportional hazard models. Findings: 17,646,115 live births were included. Prevalence of preterm birth, LBW and SGA were 9.4%, 9.6% and 9.2%, respectively. Neonatal mortality risk was 16-fold (HR = 15.9; 95% CI:15.7–16.1) higher for preterm compared to term, 3 times higher (HR = 3.4; (95% CI:3.3–3.4) for SGA compared to adequate for gestational age (AGA), and > 25 times higher for LBW (HR = 25.8; (95% CI:25.5-26.1) compared to nor- mal birth weight (NBW). 18% of all live births were included in one of the small vulnerable newborn phenotypes. Of those 8.2% were term-SGA (4.7%NBW, 3.5%LBW), 0.6% were term-AGA-LBW, 8.3% preterm- AGA (3.8%NBW, 4.5%LBW) and 1.0% preterm-SGA-LBW. Compared to term-AGA-NBW, the highest mortal- ity risk was for preterm-LBW phenotypes (HR = 36.2(95%CI 35.6-36.8) preterm-AGA-LBW, HR = 62.0(95%CI 60.8-63.2) preterm-SGA-LBW). The increased mortality risk associated with vulnerable newborn pheno- types was highest in the first month of life, with attenuated but continued high risk in the post-neonatal period and 1-4 years of age. | pt_BR |
| Affilliation | "Múltipla ver em Notas" | pt_BR |
| Subject | Premature birth | pt_BR |
| Subject | Infant mortality | pt_BR |
| Subject | Phenotype | pt_BR |
| Subject | Neonatal | pt_BR |
| Subject in Spanish | Nacimiento prematuro | pt_BR |
| Subject in Spanish | Mortalidad infantil | pt_BR |
| Subject in Spanish | Fenotipo | pt_BR |
| Subject in Spanish | Neonatal | pt_BR |
| Subject in French | Naissance prématurée | pt_BR |
| Subject in French | Mortalité infantile | pt_BR |
| Subject in French | Phénotype | pt_BR |
| Subject in French | néonatale | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
