| Author | Hitchings, Matt D. T. | |
| Author | Ranzani, Otavio T. | |
| Author | Lind, Margaret L. | |
| Author | Dorion, Murilo | |
| Author | D’Agostini, Tatiana Lang | |
| Author | Paula, Regiane Cardoso de | |
| Author | Paula, Olivia Ferreira Pereira de | |
| Author | Villela, Edlaine Faria de Moura | |
| Author | Torres, Mario Sergio Scaramuzzini | |
| Author | Oliveira, Silvano Barbosa de | |
| Author | Schulz, Wade | |
| Author | Almiron, Maria | |
| Author | Said, Rodrigo | |
| Author | Oliveira, Roberto Dias de | |
| Author | Silva, Patricia Vieira da | |
| Author | Araújo, Wildo Navegantes de | |
| Author | Gorinchteyn, Jean Carlo | |
| Author | Dean, Natalie E. | |
| Author | Andrews, Jason R. | |
| Author | Cummings, Derek A. T. | |
| Author | Ko, Albert I. | |
| Author | Croda, Julio | |
| Access date | 2022-02-14T12:47:12Z | |
| Available date | 2022-02-14T12:47:12Z | |
| Document date | 2021 | |
| Citation | HITCHINGS, Matt D. T. et.al. Change in COVID-19 risk over time following vaccination with CoronaVac: a testnegative case-control study. MedRxiv preprint, p. 1-23, 2021. | |
| URI | https://www.arca.fiocruz.br/handle/icict/51167 | |
| Sponsorship | Instituto Nacional de Alergia e Doenças Infecciosas para N.E.D. | |
| Language | eng | en_US |
| Publisher | MedRxiv | |
| Rights | open access | |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | CoronaVac | pt_BR |
| Subject in Portuguese | Vacinas | pt_BR |
| Subject in Portuguese | Vacinas de Produtos Inativados | pt_BR |
| Subject in Portuguese | Estudos de Casos e Controles | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Change in COVID-19 risk over time following vaccination with CoronaVac: a testnegative case-control study | en_US |
| Type | Preprint | |
| DOI | 10.1101/2021.12.23.21268335 | |
| Abstract | Objective To estimate the change in odds of covid-19 over time following primary series completion of the inactivated whole virus vaccine, CoronaVac (Sinovac Biotech) in São Paulo state, Brazil. Design Test negative case-control study. Setting Community testing for covid-19 in São Paulo state, Brazil. Participants Adults aged 18-120 years who were residents of São Paulo state, without a previous laboratory-confirmed covid-19 infection, who received only two doses of CoronaVac, and underwent reverse transcription polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 from 17 January to 30 September 2021. Main outcome measures RT-PCR-confirmed symptomatic covid-19 and associated hospital admissions and deaths. Cases were pair-matched to test-negative controls by age (in 5-year bands), municipality of residence, healthcare worker (HCW) status, and date of RT-PCR test (±3 days). Conditional logistic regression was adjusted for sex, number of covid-19-associated comorbidities, race, and previous acute respiratory infection. Results From 137,820 eligible individuals, 37,929 cases with symptomatic covid-19 and 25,756 testnegative controls with covid-19 symptoms were formed into 37,929 matched pairs. Adjusted odds ratios of symptomatic covid-19 increased with time since series completion, and this increase was greater in younger individuals, and among HCWs compared to non-HCWs. Adjusted odds ratios of covid-19 hospitalisation or death were significantly increased from 98 days since series completion, compared to individuals vaccinated 14-41 days previously: 1.40 (95% confidence interval 1.09 to 1.79) from 98-125 days, 1.55 (1.16 to 2.07) from 126-153 days, 1.56 (1.12 to 2.18) from 154-181 days, and 2.12 (1.39-3.22) from 182 days. Conclusions In the general population of São Paulo state, Brazil, an increase in odds of moderate and severe covid-19 outcomes was observed over time following primary series completion with CoronaVac. | en_US |
| Affilliation | University of Florida. Department of Biostatistics. College of Public Health & Health Professions. Gainesville, FL, USA. | |
| Affilliation | Barcelona Institute for Global Health. ISGlobal. Barcelona, Spain / Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas HCFMUSP. Pulmonary Division, Heart Institute (InCor). São Paulo, SP, Brazil. | |
| Affilliation | Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | |
| Affilliation | Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | |
| Affilliation | Disease Control Coordination of the São Paulo State Department of Health. São Paulo, SP, Brazil. | |
| Affilliation | Disease Control Coordination of the São Paulo State Department of Health. São Paulo, SP, Brazil. | |
| Affilliation | Disease Control Coordination of the São Paulo State Department of Health. São Paulo, SP, Brazil. | |
| Affilliation | Disease Control Coordination of the São Paulo State Department of Health. São Paulo, SP, Brazil. | |
| Affilliation | Municipal Health Secretary of Manaus. Manaus, AM, Brazil. | |
| Affilliation | Pan American Health Organization. Brasília, DF, Brazil / Universidade de Brasília. Brasília, DF, Brazil. | |
| Affilliation | Yale University School of Medicine. Department of Laboratory Medicine. New Haven, CT, USA. | |
| Affilliation | Pan American Health Organization. Brasília, DF, Brazil. | |
| Affilliation | Pan American Health Organization. Brasília, DF, Brazil. | |
| Affilliation | State University of Mato Grosso do Sul. Dourados, MS, Brazil. | |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brazil. | |
| Affilliation | Pan American Health Organization. Brasília, DF, Brazil / Universidade de Brasília, Brasília, Distrito Federal, Brazil / National Institute for Science and Technology for Health Technology Assessment. Porto Alegre, RS, Brazil. | |
| Affilliation | Health Secretariat of the State of São Paulo. São Paulo, SP, Brazil. | |
| Affilliation | Emory University. Rollins School of Public Health. Department of Biostatistics & Bioinformatics. USA. | |
| Affilliation | Stanford University, Stanford. Division of Infectious Diseases and Geographic Medicine. CA, USA. | |
| Affilliation | University of Florida. Department of Biology. Gainesville, FL, USA / University of Florida. Emerging Pathogens Institute. Gainesville, FL, USA. | |
| Affilliation | Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil. | |
| Affilliation | Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA / Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brazil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, Mato Grosso do Sul, Brazil. | |
| Subject | COVID-19 | en_US |
| Subject | CoronaVac | en_US |
| Subject | Vaccines | en_US |
| Subject | Vaccines, Inactivated | en_US |
| Subject | Case-Control Studies | en_US |
| Subject | Brazil | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
