Author | Barbosa, Katia Valéria Bastos Dias | |
Author | Teixeira, Rosângela | |
Author | Soares, Eric Bassetti | |
Author | Souza, Aécio F. Meirelles de | |
Author | Penido, Joao Milton M. O. | |
Author | Carvalho, Andrêa Teixeira de | |
Author | Martins Filho, Olindo Assis | |
Access date | 2022-02-21T13:20:33Z | |
Available date | 2022-02-21T13:20:33Z | |
Document date | 2013 | |
Citation | BARBOSA, Katia Valéria Bastos Dias et al. Phenotypic features of innate and adaptive immunity in patients with chronic hepatitis C and end-stage renal disease. Liver Int., v. 33, n. 9, p. 1349-1356, 2013. doi: 10.1111/liv.12204. | pt_BR |
ISSN | 1478-3223 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/51329 | |
Abstract in Portuguese | Background: The knowledge of the immunological profile of patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) on haemodialysis (HD) is still limited.
Aims: This study investigated the immune response profile in HCV patients with concomitant ESRD focusing on the influence of the renal disease on the phenotypic profile of peripheral blood lymphocytes.
Methods: Immunophenotypic features of peripheral blood leucocytes were assessed by flow cytometry in two distinct groups: HCV patients with ESRD (CHC+ESRD, n = 16) and HCV patients with normal renal function (CHC, n = 20). Two control groups that were included were as follows: HCV negative blood donors (BD, n = 15) and HCV negative patients with ESRD (ESRD, n = 19).
Results: Higher frequency of macrophage-like and pro-inflammatory monocytes along with enhanced frequency of CD3(-) CD16(-) CD56(+) , mainly CD56(dim) NK-cells, were the hallmark of CHC+ESRD patients. Lower frequency of B cells with significant decreased of B1 and CD23(+) B-cells were associated with ESRD, regardless the HCV infection. Although higher rates of activated CD4(+) and CD8(+) T cells were observed in the CHC and CHC+ESRD groups, the chemotaxis of T-cell subsets, based on their chemokine receptor expression, was affected by ESRD.
Conclusions: Chronic hepatitis C patients with ESRD on HD exhibit distinctive phenotypic profile of circulating leucocytes. It may be implicated in the natural history of HCV infection in this particular group of patients and warrants further investigation. | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley-Blackwell | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | cytokines | pt_BR |
Subject in Portuguese | RT-PCR | pt_BR |
Subject in Portuguese | canine diseases | pt_BR |
Subject in Portuguese | visceral leishmaniasis | pt_BR |
Subject in Portuguese | Leishmania chagasi | pt_BR |
Title | Phenotypic features of innate and adaptive immunity in patients with chronic hepatitis C and end-stage renal disease | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/liv.12204 | |
Affilliation | Universidade Federal de Juiz de Fora. Hospital Universitario. Serviço de Gastroenterologia. Juiz de Fora, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Hospital das Clınicas. Instituto Alfa de Gastroenterologia. Departamento de Clınica Medica. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Hospital das Clınicas. Instituto Alfa de Gastroenterologia. Departamento de Clınica Medica. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Hospital Universitario. Serviço de Gastroenterologia. Juiz de Fora, MG, Brazil | pt_BR |
Affilliation | Núcleo de Nefrologia de Belo Horizonte. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Subject in Spanish | chronic hepatitis C | pt_BR |
Subject in Spanish | end-stage renal disease | pt_BR |
Subject in Spanish | flow cytometry | pt_BR |
Subject in Spanish | immune response. | pt_BR |