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ANIMAL HOSTS AND EXPERIMENTAL MODELS OF SARS-COV-2 INFECTION
Hospedeiros de animais
Modelos animais
Modelos de células
Author
Affilliation
Department of Molecular Medicine, University of Padova. Padova, Italy.
National HIV/AIDS Research Center, Istituto Superiore di Sanità. Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de referência de Flavivírus. Rio de Janeiro, RJ, Brasil.
Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome. Rome, Italy.
Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. Rome, Italy.
National HIV/AIDS Research Center, Istituto Superiore di Sanità. Rome, Italy.
National HIV/AIDS Research Center, Istituto Superiore di Sanità. Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de referência de Flavivírus. Rio de Janeiro, RJ, Brasil.
Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome. Rome, Italy.
Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. Rome, Italy.
National HIV/AIDS Research Center, Istituto Superiore di Sanità. Rome, Italy.
Abstract
Viruses arise through cross-species transmission and can
cause potentially fatal diseases in humans. This is the case of
the severe acute respiratory syndrome coronavirus 2 (SARSCoV-
2) which recently appeared in Wuhan, China, and rapidly
spread worldwide, causing the outbreak of coronavirus
disease 2019 (COVID-19) and posing a global health emergency.
Sequence analysis and epidemiological investigations
suggest that the most likely original source of SARSCoV-
2 is a spillover from an animal reservoir, probably bats,
that infected humans either directly or through intermediate
animal hosts. The role of animals as reservoirs and natural
hosts in SARS-CoV-2 has to be explored, and animal models
for COVID-19 are needed as well to be evaluated for countermeasures
against SARS-CoV-2 infection. Experimental cells,
tissues, and animal models that are currently being used and
developed in COVID-19 research will be presented.
Keywords in Portuguese
Síndrome respiratória aguda grave coronavírus 2Hospedeiros de animais
Modelos animais
Modelos de células
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