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AutorFonseca, Kátia da Silva
AutorPerin, Luísa
AutorPaiva, Nívia Carolina Nogueira de
AutorSilva, Beatriz Cristiane da
AutorDuarte, Thays Helena Chaves
AutorMarques, Flávia de Souza
AutorCosta, Guilherme de Paula
AutorMolina, Israel
AutorOliveira, Rodrigo Correa de
AutorVieira, Paula Melo de Abreu
AutorCarneiro, Cláudia Martins
Data de acesso2022-02-24T16:52:38Z
Data de disponibilização2022-02-24T16:52:38Z
Data do publicação2021
CitaçãoFONSECA, Kátia da Silva et al. Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain. Pathogens, v. 10, n. 6, 729, 2021. doi.org/10.3390/pathogens10060729pt_BR
ISSN2076-0817pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/51467
Idiomaengpt_BR
EditorMDPIpt_BR
Direito Autoralopen accesspt_BR
TítuloBenznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strainpt_BR
Tipo do documentoArticlept_BR
DOI10.3390/pathogens10060729
Resumo em InglêsAs the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. Therefore, we evaluated the efficacy of different therapeutic schemes with benznidazole (BNZ) on the acute and chronic phases of the disease, using mice infected with strains that have different BNZ susceptibilities. Our results show that the groups of animals infected by VL-10 strain, when treated in the chronic phase with a lower dose of BNZ for a longer period of time (40 mg/kg/day for 40 days) presented better treatment efficacy than with the standard protocol (100 mg/kg/day for 20 days) although the best result in the treatment of the animals infected by the VL-10 strain was with100 mg/kg/day for 40 days. In the acute infection by the Y and VL-10 strains of T. cruzi, the treatment with a standard dose, but with a longer time of treatment (100 mg/kg/day for 40 days) presented the best results. Given these data, our results indicate that for BNZ, the theory of dose and time proportionality does not apply to the phases of infectionpt_BR
AfiliaçãoLaboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazilpt_BR
AfiliaçãoLaboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazilpt_BR
AfiliaçãoLaboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazilpt_BR
AfiliaçãoLaboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazilpt_BR
AfiliaçãoLaboratory of Morphopathology. Department of Biological Sciences, Nucleus of Biological Sciences Research. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazilpt_BR
AfiliaçãoLaboratory of Morphopathology. Department of Biological Sciences, Nucleus of Biological Sciences Research. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazilpt_BR
AfiliaçãoLaboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazilpt_BR
AfiliaçãoLaboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Tropical Medicine and International Health Unit, Department of Infectious Diseases, Vall d’Hebronpt_BR
AfiliaçãoLaboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Laboratory of Cellular and Molecular Immunology. René Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazilpt_BR
AfiliaçãoLaboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Laboratory of Morphopathology. Department of Biological Sciences, Nucleus of Biological Sciences Research. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazilpt_BR
AfiliaçãoLaboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Department of Clinical Analysis. School of Pharmacy. Federal University of Ouro Preto.pt_BR
Palavras-chave em inglêschagas diseasept_BR
Palavras-chave em inglêsTrypanosoma cruzipt_BR
Palavras-chave em inglêsbenznidazolept_BR
Palavras-chave em inglêstherapeutic strategiespt_BR
Palavras-chave em inglêsmicept_BR


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