| Author | Rodrigues, Nilton Barnabé | |
| Author | Godoy, Raquel Soares Maia | |
| Author | Orfano, Alessandra Silva | |
| Author | Chaves, Barbara Aparecida | |
| Author | Campolina, Thais Bonifácio | |
| Author | Costa, Breno Dos Anjos | |
| Author | Félix, Luíza Dos Santos | |
| Author | Silva, Breno Melo | |
| Author | Norris, Douglas Eric | |
| Author | Pimenta, Paulo Filemon Paolucci | |
| Author | Secundino, Nagila Francinete Costa | |
| Access date | 2022-02-24T18:32:56Z | |
| Available date | 2022-02-24T18:32:56Z | |
| Document date | 2021 | |
| Citation | RODRIGUES, Nilton Barnabé et al. Brazilian Aedes aegypti as a Competent Vector for Multiple Complex Arboviral Coinfections. J Infect Dis., v. 224, n. 1, p. 101-108, 2021.doi: 10.1093/infdis/jiab066. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51476 | |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Brazilian Aedes aegypti as a Competent Vector for Multiple Complex Arboviral Coinfections | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/infdis/jiab066. | |
| Abstract | Background: Aedes aegypti is a highly competent vector in the transmission of arboviruses, such as chikungunya, dengue, Zika, and yellow fever viruses, and causes single and coinfections in the populations of tropical countries.
Methods: The infection rate, viral abundance (VA), vector competence (VC), disseminated infection, and survival rate were recorded after single and multiple infections of the vector with 15 combinations of chikungunya, dengue, Zika, and yellow fever arboviruses.
Results: Infection rates were 100% in all single and multiple infection experiments, except in 1 triple coinfection that presented a rate of 50%. The VC and disseminated infection rate varied from 100% (in single and quadruple infections) to 40% (in dual and triple infections). The dual and triple coinfections altered the VC and/or VA of ≥1 arbovirus. The highest viral VAs were detected for a single infection with chikungunya. The VAs in quadruple infections were similar when compared with each respective single infection. A decrease in survival rates was observed in a few combinations.
Conclusions: A. aegypti was able to host all single and multiple arboviral coinfections. The interference of the chikungunya virus suggests that distinct arbovirus families may have a significant role in complex coinfections. | pt_BR |
| Affilliation | Laboratory of Medical Entomology. René Rachou Institute.. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Laboratory of Medical Entomology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Laboratory of Medical Entomology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Instituto de Pesquisas Clínicas Carlos Borborema. Manaus, Amazonas, Brazil./Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, Amazonas, Brazil. | pt_BR |
| Affilliation | Laboratory of Medical Entomology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Laboratory of Medical Entomology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Laboratory of Medical Entomology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Department of Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil. | pt_BR |
| Affilliation | W. Harry Feinstone Department of Molecular Microbiology and Immunology.Johns Hopkins Bloomberg School of Public Health. Baltimore, Maryland, USA. | pt_BR |
| Affilliation | Laboratory of Medical Entomology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Instituto de Pesquisas Clínicas Carlos Borborema. Manaus, Amazonas, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, Amazonas, Brazil. | pt_BR |
| Affilliation | Laboratory of Medical Entomology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Instituto de Pesquisas Clínicas Carlos Borborema. Manaus, Amazonas, Brazil./Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, Amazonas, Brazil. | pt_BR |
| Subject | Aedes aegypti | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | chikungunya virus | pt_BR |
| Subject | coinfection | pt_BR |
| Subject | dengue virus | pt_BR |
| Subject | yellow fever virus | pt_BR |
