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| Autor | Long, Jeffrey C | pt_BR |
| Autor | Taylor, Sarah E | pt_BR |
| Autor | Barbosa, Lucio M | pt_BR |
| Autor | Silva, Luciano Kalabric | pt_BR |
| Autor | Reis, Mitermayer G | pt_BR |
| Autor | Blanton, Ronald E | pt_BR |
| Fecha de acceso | 2022-03-03T18:14:14Z | |
| Fecha de disponibilización | 2022-03-03T18:14:14Z | |
| Fecha de publicación | 2022 | |
| Referencia | LONG, Jeffrey C. et al. Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses. Scientific Reports, v. 12, n. 1059, p. 1-12, 2022. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51526 | |
| Descripción | Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1038/s41598-022-04776-0. | en_US |
| Promoción | National Institutes of Health, USA. Grant R01AI121330 | pt_BR |
| Idioma | eng | en_US |
| Editor | Nature Research | pt_BR |
| Derechos de autor | open access | pt_BR |
| Palabras clave en Portugués | Esquistossomose mansoni | pt_BR |
| Palabras clave en Portugués | Mortalidade | pt_BR |
| Palabras clave en Portugués | Parasitos | pt_BR |
| Palabras clave en Portugués | Genômica | pt_BR |
| Título | Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses | en_US |
| Tipo del documento | Article | pt_BR |
| DOI | 10.1038/s41598-022-04776-0 | pt_BR |
| Resumen en Inglés | Patterns of diversity in pathogen genomes provide a window into the spatiotemporal spread of disease. In this study, we tested the hypothesis that Schistosoma mansoni parasites form genetic clusters that coincide with the communities of their human hosts. We also looked for genetic clustering of parasites at the sub-community level. Our data consists of 14 microsatellite DNA markers, typed from pooled DNA samples from N = 254 infected individuals living in three Brazilian communities. We found a one-to-one correspondence between genetic clusters found by K-means cluster analysis and communities when K = 3. These clusters are also easily identifed in a neighborjoining tree and principal coordinates plots. K-means analysis with K > 3 also reveals genetic clusters of parasites at the sub-community level. These sub-clusters also appear on the neighbor-joining tree and principal coordinates plots. A surprising fnding is a genetic relationship between subgroups in widely separated human communities. This connection suggests the existence of common transmission sites that have wide infuence. In summary, the genetic structure of S. mansoni in Brazil juxtaposes local isolation that is occasionally broken by long-range migration. Permanent eradication of schistosomes will require both local eforts and the identifcation of regional infection reservoirs. | en_US |
| Afiliación | University of New Mexico. Department of Anthropology. Albuquerque, NM, USA. | en_US |
| Afiliación | University of New Mexico. Department of Anthropology. Albuquerque, NM, USA. | en_US |
| Afiliación | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Yale University. Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA. | pt_BR |
| Afiliación | Tulane University. School of Public Health and Tropical Medicine. Department of Tropical Medicine. New Orleans, LA, USA. | en_US |
| Palavras clave en Inglês | Schistosomiasis mansoni | en_US |
| Palavras clave en Inglês | Mortality | en_US |
| Palavras clave en Inglês | Parasites | en_US |
| Palavras clave en Inglês | Genomics | en_US |
| Palavras clave | Esquistosomiasis mansoni | es_ES |
| Palavras clave | Mortalidad | es_ES |
| Palavras clave | Parásitos | es_ES |
| Palavras clave | Genómica | es_ES |
| Palavras clave en Francês | Schistosomiase mansoni | fr_FR |
| Palavras clave en Francês | Mortalité | fr_FR |
| Palavras clave en Francês | Parasites | fr_FR |
| Palavras clave en Francês | Génomique | fr_FR |
| DeCS | Esquistossomose mansoni | pt_BR |
| DeCS | Mortalidade | pt_BR |
| DeCS | Parasitos | pt_BR |
| DeCS | Genômica | pt_BR |
| e-ISSN | 2045-2322 | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar |
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