| Author | Borba, Pedro B | |
| Author | Meneguin, Andréia Bagliotti | |
| Author | Silva, Jhonatan Miguel | |
| Author | Barud, Hernane da Silva | |
| Author | Oliveira, Camila I. de | |
| Access date | 2022-03-07T14:47:52Z | |
| Available date | 2022-03-07T14:47:52Z | |
| Document date | 2022 | |
| Citation | BORBA, Pedro B. et al. Bacterial nanocellulose containing diethylditiocarbamate bio-curatives: physicochemical characterization and drug delivery evaluation. Cellulose, v. 29, p. 1-9, 2022. | pt_BR |
| ISSN | 1572-882X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51585 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Universidade de Araraquara. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Ditiocarb | pt_BR |
| Title | Bacterial nanocellulose containing diethylditiocarbamate bio-curatives: physicochemical characterization and drug delivery evaluation | pt_BR |
| Type | Article | |
| DOI | 10.1007/s10570-021-04360-1 | pt_BR |
| Abstract | Bacterial nanocellulose (BNC) is a natural biopolymer produced by different strains of acetic acid bacteria. Biocompatibility, lack of immunogenicity, mechanical strength and crystallinity make BNC a highly applicable product for drug delivery and wound dressing. Previously, we demonstrated that diethylditiocarbamate (DETC), a Superoxide Dismutase 1 inhibitor, incorporated into BNC bio-curatives was effective for treating Cutaneous leishmaniasis (CL) lesions, a parasitic disease caused by Leishmania. We herein investigated the interactions between DETC and BNC. For this purpose, DETC was incorporated into BNC and thermal analysis, x-ray diffraction and Scanning electron microscopy were performed. Furthermore, in vitro DETC release and stability tests as well as degradation studies were also performed. Our results show that DETC is well incorporated into BNC, however it is short lived as suggested by degradation experiments. Future use of BNC DETC-based bio-curatives for the treatment of CL shall require further development in order to increase stability of DETC in the bio-curative. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade do Estado de São Paulo. Faculdade de Ciências Farmacêuticas. Araraquara, SP, Brasil. | pt_BR |
| Affilliation | Universidade de Araraquara. Araraquara, SP, Brasil. | pt_BR |
| Affilliation | Universidade de Araraquara. Araraquara, SP, Brasil. | pt_BR |
| Affilliation | Instituto de Investigação em Doenças Tropicais. Salvador, BA, Brasil. | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| Subject | Topical delivery | pt_BR |
| Subject | Diethylditiocarbamate | pt_BR |
| Subject | Degradation | pt_BR |
| Subject in Spanish | Leishmaniasis | pt_BR |
| Subject in Spanish | Ditiocarba | pt_BR |
| Subject in French | Leishmaniose | pt_BR |
| Subject in French | Acide diéthyl-dithiocarbamique | pt_BR |
