| Author | Silva, Amanda C. O | |
| Author | Bonfim, Maiara | |
| Author | Fontes, Jonathan L. M | |
| Author | Santos, Washington L. C. dos | |
| Author | Mengel, José | |
| Author | Cardillo, Fabíola | |
| Access date | 2022-03-07T18:24:30Z | |
| Available date | 2022-03-07T18:24:30Z | |
| Document date | 2022 | |
| Citation | Silva, Amanda C. O et al. C57BL/6 mice pretreated with alpha-tocopherol show a better outcome of trypanosoma cruzi infection with less tissue inflammation and fibrosis. Frontiers in Immunology, v. 13, p. 1-10, 2022. | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51599 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Fundação Octácilio Gualberto (FOG). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Doença de chagas | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Fibrose | pt_BR |
| Subject in Portuguese | Imunomodulação | pt_BR |
| Subject in Portuguese | Interleucina-10 | pt_BR |
| Subject in Portuguese | Interferon gama | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Title | C57BL/6 mice pretreated with alpha-tocopherol show a better outcome of trypanosoma cruzi infection with less tissue inflammation and fibrosis | pt_BR |
| Type | Article | pt_BR |
| DOI | doi.org/10.3389/fimmu.2022.833560 | |
| Abstract | Chagas disease is accompanied by a multisystem inflammatory disorder that follows Trypanosoma cruzi infection. Alpha-tocopherol has been described as an antioxidant and a potential adjuvant to enhance immune responses to vaccines. Therefore, we have evaluated the immune response to T. cruzi infection upon alpha-tocopherol pre-administration. The results show that administration of alpha-tocopherol before the infection results in lower parasitemia and lower mortality of C57BL/6 mice infected with the Tulahuen T. cruzi strain. Alpha-tocopherol administration in normal C57BL/6 mice resulted in higher levels of IFN-γ production by T and NK cells before and after the infection with T. cruzi. More importantly, previous administration of alpha-tocopherol increased the production of IL-10 by T and myeloid suppressor cells and the formation of effector memory T cells while decreasing the expression of PD-1 on T cells. These results suggest that alpha-tocopherol may limit the appearance of dysfunctional T cells during the acute and early chronic phases of T. cruzi infection, contributing to control infection. In addition, alpha-tocopherol could diminish tissue inflammation and fibrosis in late acute disease. These results strongly suggest that alpha-tocopherol may be a helpful agent to be considered in Chagas disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Molecular e Estrutural. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Molecular e Estrutural. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Molecular e Estrutural. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Molecular e Estrutural. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Patologia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Centro Universitário Arthur Sá Earp Neto (UNIFASE). Faculdade de Medicina de Petrópolis. Petrópolis, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Molecular e Estrutural. Salvador, BA, Brasil. | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Fibrosis | pt_BR |
| Subject | Immunomodulation | pt_BR |
| Subject | Interleukin-10 | pt_BR |
| Subject | Interferon-gamma | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject in Spanish | Enfermedad de chagas | pt_BR |
| Subject in Spanish | Trypanosoma cruzi | pt_BR |
| Subject in Spanish | Fibrosis | pt_BR |
| Subject in Spanish | Inmunomodulación | pt_BR |
| Subject in Spanish | Interleucina-10 | pt_BR |
| Subject in Spanish | Interferón gamma | pt_BR |
| Subject in Spanish | Inflamación | pt_BR |
| Subject in French | Maladie de chagas | pt_BR |
| Subject in French | Trypanosoma cruzi | pt_BR |
| Subject in French | Fibrose | pt_BR |
| Subject in French | Immunomodulation | pt_BR |
| Subject in French | Interleukine-10 | pt_BR |
| Subject in French | Interféron gamma | pt_BR |
| Subject in French | Inflammation | pt_BR |
