| Author | Starling, Ana Lúcia Borges | |
| Author | Pereira, Sílvio Roberto Souza | |
| Author | Pascoal, Vanessa Peruhype Magalhães | |
| Author | Reis, Jordana Grazziela Alves Coelho Dos | |
| Author | Bicalho, Kelly Alves | |
| Author | Paiva, Luciene Pimenta de | |
| Author | Martins, Julia Pereira | |
| Author | Trindade, Bruno Caetano | |
| Author | Labanca, Ludimila | |
| Author | Faccioli, Lúcia Helena | |
| Author | Lambertucci, José Roberto | |
| Author | Silva, Luciana Cristina Dos Santos | |
| Author | Antunes, Carlos Maurício de Figueiredo | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Proietti, Anna Bárbara de Freitas Carneiro | |
| Author | Gonçalves, Denise Ustch | |
| Author | Martins Filho, Olindo Assis | |
| Access date | 2022-03-07T19:15:28Z | |
| Available date | 2022-03-07T19:15:28Z | |
| Document date | 2021 | |
| Citation | STARLING, Ana Lúcia Borges et al. Impact of HIV co-infection on immunological biomarker profile of HTLV-1 infected patients. Immunol Lett., v. 236, p. 68-77, 2021. doi: 10.1016/j.imlet.2021.05.009. | pt_BR |
| ISSN | 0165-2478 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51602 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Impact of HIV co-infection on immunological biomarker profile of HTLV-1 infected patients | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.imlet.2021.05.009. | |
| Abstract | The impact of HIV co-infection on the plasma immunological biomarker profile of HTLV-1 infected patients was evaluated. The plasma levels of leukotrienes and chemokines/cytokines were quantified by ELISA and Cytometric Bead Array. A total of 138 volunteers were enrolled and divided into two subgroups ("HTLV-1(+)HIV(-)" and "HTLV-1(+)(HIV(+)"), which were categorized according to the HTLV-1-associated neurological disease (AS, pHAM and HAM). Reference controls were BD and HIV mono-infected patients. HAM(+) exhibited higher CD4+ T-cell counts as compared to HIV+ mono-infected patients and lower HTLV-1 proviral load as compared to mono-infected HAM(-) patients. AS(+) exhibited higher levels of CysLT, CXCL8/IL-8 and lower levels of CCL5/RANTES as compared to AS(-). Increased levels of IL-6 and TNF with reduced levels of CXCL10/IP10 and CCL5/RANTES were observed in co-infected pHAM(+) as compared to mono-infected pHAM(-). HAM(+) patients revealed an increase in CXCL8/IL-8, CCL2/MCP-1, CXCL-10/IP-10, TNF and a decrease in IL-2 as compared to HAM(-) subgroup. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Faculdade de Farmácia, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação HEMOMINAS. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Interdisciplinar de Pesquisa em HTLV. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Biomarkers | pt_BR |
| Subject | Chemokines | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | HTLV-1 | pt_BR |
| Subject | HTLV-1/HIV co infection | pt_BR |
| Subject | Leukotrienes | pt_BR |
