| Author | Liu, Chang | |
| Author | Ginn, Helen M. | |
| Author | Dejnirattisai, Wanwisa | |
| Author | Supasa, Piyada | |
| Author | Wang, Beibei | |
| Author | Tuekprakhon, Aekkachai | |
| Author | Nutalai, Rungtiwa | |
| Author | Zhou, Daming | |
| Author | Mentzer, Alexander J. | |
| Author | Zhao, Yuguang | |
| Author | Duyvesteyn, Helen M.E. | |
| Author | López-Camacho, César | |
| Author | Slon-Campos, Jose | |
| Author | Walter, Thomas S. | |
| Author | Skelly, Donal | |
| Author | Johnson, Sile Ann | |
| Author | Ritter, Thomas G. | |
| Author | Mason, Chris | |
| Author | Clemens, Sue Ann Costa | |
| Author | Naveca, Felipe Gomes | |
| Author | Nascimento, Valdinete | |
| Author | Nascimento, Fernanda | |
| Author | Costa, Cristiano Fernandes da | |
| Author | Resende, Paola Cristina | |
| Author | Pauvolid-Correa, Alex | |
| Author | Siqueira, Marilda Agudo Mendonça Teixeira de | |
| Author | Dold, Christina | |
| Author | Temperton, Nigel | |
| Author | Dong, Tao | |
| Access date | 2022-03-07T21:47:50Z | |
| Available date | 2022-03-07T21:47:50Z | |
| Document date | 2021 | |
| Citation | LIU, CHANG et al. Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum. Cell, 184, p. 4220-4236, Aug. 2021. | pt_BR |
| ISSN | 0092-8674 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51604 | |
| Description | Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/ | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Previous version | https://www.arca.fiocruz.br/handle/icict/47927 | pt_BR |
| Rights | open access | |
| Subject in Portuguese | SARS-CoV-2 B.1.617 | pt_BR |
| Subject in Portuguese | Neutralização reduzida | pt_BR |
| Subject in Portuguese | Vacina | pt_BR |
| Subject in Portuguese | Soro convalescente | pt_BR |
| Subject in Portuguese | Rede Genômica Fiocruz | pt_BR |
| Subject in Portuguese | GENOMAHCOV | pt_BR |
| Subject in Portuguese | COVID-19 | |
| Title | Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.cell.2021.06.020 | |
| Abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with
variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased
transmissibility, variant B.1.617.2 has contributed to the current wave of infection ravaging the Indian subcontinent
and has been designated a variant of concern in the United Kingdom. Here we study the ability
of monoclonal antibodies and convalescent and vaccine sera to neutralize B.1.617.1 and B.1.617.2, complement
this with structural analyses of Fab/receptor binding domain (RBD) complexes, and map the antigenic
space of current variants. Neutralization of both viruses is reduced compared with ancestral Wuhan-related
strains, but there is no evidence of widespread antibody escape as seen with B.1.351. However, B.1.351 and
P.1 sera showed markedly more reduction in neutralization of B.1.617.2, suggesting that individuals infected
previously by these variants may be more susceptible to reinfection by B.1.617.2. This observation provides
important new insights for immunization policy with future variant vaccines in non-immune populations. | pt_BR |
| Affilliation | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK / Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Diamond Light Source Ltd., Harwell Science & Innovation Campus, Didcot, UK. | pt_BR |
| Affilliation | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Division of Structural Biology, The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK / Oxford University Hospitals NHS Foundation Trust, Oxford, UK. | pt_BR |
| Affilliation | Division of Structural Biology, The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK | pt_BR |
| Affilliation | Division of Structural Biology, The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK | pt_BR |
| Affilliation | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK | pt_BR |
| Affilliation | Division of Structural Biology, The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Oxford University Hospitals NHS Foundation Trust, Oxford, UK / Peter Medawar Building for Pathogen Research, Oxford, UK / Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Peter Medawar Building for Pathogen Research, Oxford, UK. | pt_BR |
| Affilliation | Oxford University Hospitals NHS Foundation Trust, Oxford, UK | pt_BR |
| Affilliation | Oxford University Hospitals NHS Foundation Trust, Oxford, UK | pt_BR |
| Affilliation | Institute of Global Health, University of Siena, Siena, Italy / Department of Paediatrics, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil | pt_BR |
| Affilliation | Fundação de Vigilãncia em Saúde do Amazonas, Manaus, AM, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil / Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | NIHR Oxford Biomedical Research Centre, Oxford, UK / Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. | pt_BR |
| Affilliation | Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and Greenwich, Chatham Maritime, Kent ME4 4TB, UK. | pt_BR |
| Affilliation | Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK / Nuffield Department of Medicine, University of Oxford, Oxford, UK / MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK, | pt_BR |
| Subject | SARS-CoV-2 B.1.617 | pt_BR |
| Subject | Reduced neutralization | pt_BR |
| Subject | Vaccine | pt_BR |
| Subject | Convalescent serum | pt_BR |
| Subject | COVID-19 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
