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RAPID EPIDEMIC EXPANSION OF THE SARS-COV-2 OMICRON VARIANT IN SOUTHERN AFRICA
Múltipla autoria - ver em Notas | Fecha del documento:
2022
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Resumen en ingles
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in
southern Africa has been characterised by three distinct waves. The first was
associated with a mix of SARS-CoV-2 lineages, whilst the second and third waves were
driven by the Beta and Delta variants, respectively1–3. In November 2021, genomic
surveillance teams in South Africa and Botswana detected a new SARS-CoV-2 variant
associated with a rapid resurgence of infections in Gauteng Province, South Africa.
Within three days of the first genome being uploaded, it was designated a variant of
concern (Omicron) by the World Health Organization and, within three weeks, had
been identified in 87 countries. The Omicron variant is exceptional for carrying over
30 mutations in the spike glycoprotein, predicted to influence antibody
neutralization and spike function4. Here, we describe the genomic profile and early
transmission dynamics of Omicron, highlighting the rapid spread in regions with high
levels of population immunity.
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