| Author | Carvalho, Lilian V.S | |
| Author | Souza, Cassiana da Silva | |
| Author | Fontes, Jonathan L.M | |
| Author | Cardoso, Lara | |
| Author | Salomar, Milton | |
| Author | Duarte Neto, Amaro Nunes | |
| Author | Figueira, Claudio | |
| Author | Brito, Reginaldo | |
| Author | Mesquita, Bianca | |
| Author | Freitas, Luiz A.R. de | |
| Author | Oliveira, Geraldo G.S | |
| Author | Santos, Washington L. C. dos | |
| Access date | 2022-03-10T14:33:44Z | |
| Available date | 2022-03-10T14:33:44Z | |
| Document date | 2022 | |
| Citation | Carvalho, Lilian V.S. et al. COVID-19 beyond DAD: persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease. Human Pathology, v. 27, p. 1-4, 2022. | pt_BR |
| ISSN | 0046-8177 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51674 | |
| Sponsorship | Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). FIOCRUZ Inova | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | Autopsia | pt_BR |
| Subject in Portuguese | Coagulação Intravascular Disseminada | pt_BR |
| Title | COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease | pt_BR |
| Type | Article | pt_BR |
| DOI | doi.org/10.1016/j.hpr.2022.300607 | |
| Abstract | Background: Despite advances in the management of COVID-19, some events occurring in the course of disease still represent challenges to patient treatment. Case presentation: Here we present a case of severe COVID-19 in which the patient received standard treatment including dexamethasone and prophylactic anticoagulation and died on the 24th day of disease. Autopsy showed exudative and proliferative DAD accompanied by remaining microcirculation thrombosis despite anticoagulation treatment, unperceived fungal infection, concomitantly with the presence of dense acellular fibrotic areas amidst organizing lung lesions. Conclusions: Although improvements were achieved in COVID-19 therapeutics lung microcirculation coagulopathy, unperceived fungus infection and early developing alveolar fibrosis remain unsolved problems associated to the disease. | pt_BR |
| Affilliation | Instituto Couto Maia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Instituto Couto Maia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil. | pt_BR |
| Subject | COVID-19 | pt_BR |
| Subject | Autopsy | pt_BR |
| Subject | Disseminated Intravascular Coagulation | pt_BR |
| Subject in Spanish | COVID-19 | pt_BR |
| Subject in Spanish | Autopsia | pt_BR |
| Subject in Spanish | Coagulación Intravascular Diseminada | pt_BR |
| Subject in French | Coronavirus | pt_BR |
| Subject in French | Autopsie | pt_BR |
| Subject in French | Coagulation intravasculaire disséminée | pt_BR |
