| Author | Ferreira, Tatiana Paula Teixeira | |
| Author | Guimarães, Fernanda Verdini | |
| Author | Sá, Yago Amigo Pinho Jannini | |
| Author | Ribeiro, Natalia Barreto da Silva | |
| Author | Arantes, Ana Carolina Santos de | |
| Author | Carvalho, Vinicius de Frias | |
| Author | Sousa, Lirlândia Pires | |
| Author | Perretti, Mauro | |
| Author | Martins, Marco Aurélio | |
| Author | Silva, Patrícia Machado Rodrigues e | |
| Access date | 2022-03-17T20:33:28Z | |
| Available date | 2022-03-17T20:33:28Z | |
| Document date | 2022 | |
| Citation | FERREIRA, Tatiana Paula Teixeira et al. Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice. Cells, v. 11, n. 759, p. 1 - 13, Feb. 2022. | pt_BR |
| ISSN | 2073-4409 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51734 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Pulmão | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Remodelação | pt_BR |
| Subject in Portuguese | Asma alérgica | pt_BR |
| Subject in Portuguese | Terapia | pt_BR |
| Subject in Portuguese | Peptídeo Ac2-26 | pt_BR |
| Title | Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice | pt_BR |
| Type | Article | |
| DOI | 10.3390/cells11050759 | |
| Abstract | Annexin-A1 (AnxA1) and its N-terminal derived peptide Ac2-26 regulate the inflammatory
response in several experimental models of disorders. This study evaluated the effect of endogenous
AnxA1 and its N-terminal peptide Acetyl 2-26 (Ac2-26) on allergic asthma triggered by house dust
mite (HDM) extract in mice. ANXA1/ and wildtype (WT) mice were exposed to intranasal
instillation of HDM every other day for 3 weeks, with analyses performed 24 h following the last
exposure. Intranasal administration of peptide Ac2-26 was performed 1 h before HDM, beginning
1 week after the initial antigen application. ANXA1/ mice stimulated with HDM showed marked
exacerbations of airway hyperreactivity (AHR), eosinophil accumulation, subepithelial fibrosis, and
mucus hypersecretion, all parameters correlating with overexpression of cytokines (IL-4, IL-13, TNF- ,
and TGF- ) and chemokines (CCL11/eotaxin-1 and CCL2/MCP-1). Intranasal treatment with peptide
Ac2-26 decreased eosinophil infiltration, peribronchiolar fibrosis, and mucus exacerbation caused
by the allergen challenge. Ac2-26 also inhibited AHR and mediator production. Collectively, our
findings show that the AnxA1-derived peptide Ac2-26 protects against several pathological changes
associated with HDM allergic reaction, suggesting that this peptide or related AnxA1-mimetic Ac2-26
may represent promising therapeutic candidates for the treatment of allergic asthma. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Unversidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Department of Biochemical Pharmacology, The William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Lung | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Remodelling | pt_BR |
| Subject | Allergic asthma | pt_BR |
| Subject | Therapy | pt_BR |
| Subject | peptide Ac2-26 | pt_BR |
